{"id":"W4360605228","doi":"10.1101/2023.03.20.533468","title":"Compromised beta-cell identity in type 2 diabetes","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Horizon 2020 Framework Programme; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Universiteit van Amsterdam; ZonMw","keywords":"PDX1; Beta cell; Insulin; Transcription factor; Downregulation and upregulation; Biology; Cell biology; BETA (programming language); FOXO1; Cell; Transcription (linguistics); Secretion; Type 2 diabetes; Endocrinology; Internal medicine; Gene; Diabetes mellitus; Islet; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000155677,0.0003528639,0.0003601508,0.0001572142,0.0001861998,0.000621177,0.000333363,0.000585728,0.00240518],"category_scores_gemma":[0.0003526295,0.0001941624,0.0005756525,0.0001725295,0.0002746686,0.0003277689,0.000432595,0.0005159641,0.0001833967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000455094,"about_ca_system_score_gemma":0.0003834285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003261579,"about_ca_topic_score_gemma":0.001627655,"domain_scores_codex":[0.9999409,0.00001669839,0.000002298102,0.0000141634,0.00001178847,0.00001419711],"domain_scores_gemma":[0.9998903,0.00004196625,0.00003293039,0.000005875447,0.000009815136,0.00001914989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001092572,0.00008926893,0.004053107,0.00005686727,0.00004554995,0.0003052477,0.00003492749,0.9765307,0.009846046,0.006180521,0.000391438,0.002357],"study_design_scores_gemma":[0.00005618892,0.0001282537,0.002436484,0.00001990823,0.00003505044,0.00009441514,0.00003335375,0.9893227,0.001647904,0.004689998,0.001520845,0.00001493428],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8929813,0.001392282,0.08672517,0.000624213,0.0001646476,0.00004260907,0.0004519221,0.0001400255,0.01747791],"genre_scores_gemma":[0.9905129,0.0005065762,0.005693105,0.0000925887,0.00001763308,0.00005137095,0.0001345564,0.00002246199,0.002968878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003261579,"threshold_uncertainty_score":0.008046091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0260654833210764,"score_gpt":0.2512728221527816,"score_spread":0.2252073388317052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}