{"id":"W4360609373","doi":"10.1371/journal.pone.0279991","title":"Characterization of methylation profiles in spontaneous preterm birth placental villous tissue","year":2023,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Preterm Birth and Chorioamnionitis","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; March of Dimes Prematurity Research Center Ohio Collaborative; U.S. Department of Health and Human Services; March of Dimes Foundation; National Institutes of Health; University of Cincinnati; University of Minnesota","keywords":"DNA methylation; Methylation; Placenta; Biology; Gestation; Placentation; Andrology; Gestational age; Pregnancy; Obstetrics; Fetus; Medicine; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001005813,0.00009234424,0.0002484614,0.0002096966,0.00002068469,0.000007703563,0.00005291447,0.00007870758,0.000156034],"category_scores_gemma":[0.00008855179,0.00009209685,0.00002496111,0.0003164948,0.00002563153,0.00008093523,0.00002695937,0.00009877968,0.00006982301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004714774,"about_ca_system_score_gemma":0.000037451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000192161,"about_ca_topic_score_gemma":0.00001686801,"domain_scores_codex":[0.9990719,0.00003599505,0.0002453721,0.0001640735,0.0003071565,0.0001755052],"domain_scores_gemma":[0.9996124,0.0000322399,0.00008600222,0.0001536554,0.00005142315,0.00006426869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002706996,0.0002708862,0.03246843,0.0003857548,0.00003843107,0.0002458224,0.0005466338,5.100324e-7,0.9613088,0.00001433422,0.000004541787,0.004445179],"study_design_scores_gemma":[0.000923351,0.0003885499,0.2387301,0.0004817851,0.00004996969,0.00005456973,0.00004415094,0.0009317025,0.7581707,0.00002968845,0.00009140201,0.0001040229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982129,0.00003315059,0.000007263626,0.0001956225,0.00004792679,0.0006181723,0.00008537326,0.0001186221,0.0006810053],"genre_scores_gemma":[0.9978558,0.0002026285,0.0001923937,0.00004121564,0.00009730498,0.0000433156,0.0006176385,0.00002097784,0.000928726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2062616,"threshold_uncertainty_score":0.3755601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02538635294515166,"score_gpt":0.2419734362237541,"score_spread":0.2165870832786025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}