{"id":"W4360613294","doi":"10.1136/bmjopen-2022-063605","title":"The Pyruvate Kinase Deficiency Global Longitudinal (Peak) Registry: rationale and study design","year":2023,"lang":"en","type":"article","venue":"BMJ Open","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Agios Pharmaceuticals","keywords":"Medicine; Pyruvate kinase; Pyruvate kinase deficiency; Internal medicine; Glycolysis; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000887662,0.00009135982,0.0001626893,0.00002023819,0.0003390494,0.00008287826,0.0001642778,0.00003563732,0.00006645999],"category_scores_gemma":[0.0003133004,0.00005918887,0.00002531179,0.0003269635,0.0000866843,0.00006509906,0.0002374465,0.0000752603,0.0002425457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003103973,"about_ca_system_score_gemma":0.0001865022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008817916,"about_ca_topic_score_gemma":0.00009900811,"domain_scores_codex":[0.9990603,0.0001437362,0.0001798789,0.0002512076,0.0001857982,0.0001790783],"domain_scores_gemma":[0.9992983,0.0001401494,0.00006737637,0.0003488348,0.00007032588,0.00007503924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.01066659,0.00133395,0.4384998,0.0002431964,0.0003234747,0.001703028,0.001994557,0.0004153353,0.006167255,0.01432215,0.50273,0.02160067],"study_design_scores_gemma":[0.003031169,0.001513873,0.9771718,0.00005858727,0.00007138155,0.0001203533,0.002424345,0.0007731538,0.00005473667,0.001579092,0.01303754,0.0001639935],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9667426,0.0002065717,0.0005765061,0.006911218,0.0005995572,0.01195183,0.00002124412,0.0001271325,0.01286328],"genre_scores_gemma":[0.9868004,0.00007228705,0.0003511164,0.000669533,0.0002144462,0.0009291853,0.00004056425,0.00001307872,0.01090943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.538672,"threshold_uncertainty_score":0.3117515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.169422006976724,"score_gpt":0.4125378679585567,"score_spread":0.2431158609818327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}