{"id":"W4360613294","doi":"10.1136/bmjopen-2022-063605","title":"The Pyruvate Kinase Deficiency Global Longitudinal (Peak) Registry: rationale and study design","year":2023,"lang":"en","type":"article","venue":"BMJ Open","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Agios Pharmaceuticals","keywords":"Medicine; Pyruvate kinase; Pyruvate kinase deficiency; Internal medicine; Glycolysis; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.09251973,0.001675264,0.001939568,0.002254482,0.001866588,0.002891683,0.003624309,0.003429001,0.01850042],"category_scores_gemma":[0.07386655,0.001555894,0.001460031,0.003866486,0.002677497,0.002883571,0.002698408,0.002880325,0.006419617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001674843,"about_ca_system_score_gemma":0.01402303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001225852,"about_ca_topic_score_gemma":0.002047856,"domain_scores_codex":[0.9385117,0.04893507,0.005034406,0.0031478,0.003408653,0.000962321],"domain_scores_gemma":[0.9641497,0.01292401,0.005189518,0.00690109,0.008423259,0.002412384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.09551451,0.006941317,0.1305224,0.05584741,0.003077451,0.002779107,0.006907843,0.004383645,0.003631978,0.110861,0.3162665,0.2632668],"study_design_scores_gemma":[0.0478663,0.01975352,0.06107231,0.04366044,0.002968444,0.003094543,0.003826111,0.007303758,0.003136115,0.03905997,0.7677599,0.0004985782],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01554697,0.006337774,0.04519179,0.008542061,0.00301605,0.8901279,0.02154993,0.0002222324,0.009465331],"genre_scores_gemma":[0.02955196,0.001613181,0.04437546,0.004695292,0.00066418,0.9141954,0.00354999,0.00005140308,0.001303329],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.09251973,"threshold_uncertainty_score":0.489297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.169422006976724,"score_gpt":0.4125378679585567,"score_spread":0.2431158609818327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}