{"id":"W4360615761","doi":"10.2147/tacg.s401712","title":"Genetic Loss of Sucrase-Isomaltase Function: Mechanisms, Implications, and Future Perspectives","year":2023,"lang":"en","type":"review","venue":"The Application of Clinical Genetics","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novo Nordisk Foundation Center for Basic Metabolic Research; Novo Nordisk Fonden; Copenhagen Graduate School for Nanoscience and Nanotechnology; Novo Nordisk","keywords":"Function (biology); Loss function; Computational biology; Biology; Evolutionary biology; Medicine; Genetics; Bioinformatics; Gene; Phenotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005931191,0.0005014861,0.0009037519,0.0006952507,0.0001683374,0.0009647232,0.0005326503,0.0009545498,0.002301411],"category_scores_gemma":[0.0005246269,0.000114726,0.0004875424,0.0009403761,0.0004986107,0.0008890692,0.0004167937,0.001209155,0.0005514241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006764009,"about_ca_system_score_gemma":0.0008986999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001057149,"about_ca_topic_score_gemma":0.001452619,"domain_scores_codex":[0.9998536,0.00003311271,0.00001805651,0.00003534662,0.00003210349,0.0000278846],"domain_scores_gemma":[0.9996948,0.000107517,0.00006417857,0.000007254773,0.00008460849,0.00004157923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009610292,0.0001406692,0.00492698,0.03681961,0.0007290957,0.003526442,0.00044376,0.001389434,0.03237002,0.02451431,0.04330893,0.8508697],"study_design_scores_gemma":[0.0000894493,0.0006217925,0.01469636,0.008704013,0.0006767295,0.00962759,0.0008404908,0.001112711,0.005796697,0.02117838,0.9365585,0.00009719951],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00156418,0.994474,0.000385385,0.002148631,0.0004177175,0.000003521669,0.00004923462,0.00001434562,0.000942957],"genre_scores_gemma":[0.008078955,0.9895816,0.0003892252,0.0006578051,0.00047626,0.000008400419,0.00007862874,0.000003390116,0.0007257612],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002301411,"threshold_uncertainty_score":0.007699013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05989780976577334,"score_gpt":0.418380377968249,"score_spread":0.3584825682024756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}