{"id":"W4360807082","doi":"10.1111/cpr.13457","title":"<scp>PR‐DUB</scp> safeguards Polycomb repression through <scp>H2AK119ub1</scp> restriction","year":2023,"lang":"en","type":"article","venue":"Cell Proliferation","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Key Research and Development Program of China; Tianjin Medical University; Institute of Biophysics, Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"Polycomb-group proteins; Chromatin; PRC2; Biology; Histone; Psychological repression; Cell fate determination; Epigenomics; Cell biology; Genetics; Gene silencing; Epigenome; Embryonic stem cell; Transcription factor; Gene; Repressor; DNA methylation; Histone H3; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000820175,0.0002581319,0.0001752751,0.0002127865,0.0001582496,0.0003757012,0.0001918898,0.000147983,0.001107756],"category_scores_gemma":[0.00006281206,0.0001100126,0.0001766424,0.0001943273,0.0002197915,0.0001729186,0.0003255451,0.0003251183,0.0003615678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002171115,"about_ca_system_score_gemma":0.000129056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006313972,"about_ca_topic_score_gemma":0.001133669,"domain_scores_codex":[0.9998658,0.00001230875,0.000011716,0.00003984236,0.00004684211,0.00002349648],"domain_scores_gemma":[0.9999138,0.000007159535,0.00003073819,0.0000178038,0.00001090622,0.0000196656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001693772,0.000002267169,0.0002932899,0.00001499045,0.000003083529,0.000032574,0.000004836475,0.00003854468,0.9987534,0.00005963793,0.00001653614,0.0007639187],"study_design_scores_gemma":[0.000002325633,0.00003052549,0.01058736,0.000002186304,0.000008514185,0.0002955016,0.00001777293,0.000603943,0.985754,0.00004539783,0.002649639,0.000002848527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866515,0.001367784,0.008595736,0.00006620515,0.00001492858,0.00001656103,0.001011285,0.0002413273,0.002034524],"genre_scores_gemma":[0.993569,0.0004368677,0.001711203,0.0000277372,0.000004894375,0.00001452137,0.0009268091,0.00005059909,0.003258534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001107756,"threshold_uncertainty_score":0.0037058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01688824118099035,"score_gpt":0.2665214025367252,"score_spread":0.2496331613557348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}