{"id":"W4360807082","doi":"10.1111/cpr.13457","title":"<scp>PR‐DUB</scp> safeguards Polycomb repression through <scp>H2AK119ub1</scp> restriction","year":2023,"lang":"en","type":"article","venue":"Cell Proliferation","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Key Research and Development Program of China; Tianjin Medical University; Institute of Biophysics, Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"Polycomb-group proteins; Chromatin; PRC2; Biology; Histone; Psychological repression; Cell fate determination; Epigenomics; Cell biology; Genetics; Gene silencing; Epigenome; Embryonic stem cell; Transcription factor; Gene; Repressor; DNA methylation; Histone H3; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005353004,0.000295366,0.0002145808,0.0001457055,0.0003664021,0.0001291794,0.0002071756,0.0004788153,0.000008407524],"category_scores_gemma":[0.0006995574,0.000296871,0.0001410607,0.0004943568,0.00005385852,0.00003339186,0.0001533302,0.0002149903,0.0002182433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000420274,"about_ca_system_score_gemma":0.0001239585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003161166,"about_ca_topic_score_gemma":0.00001377109,"domain_scores_codex":[0.9976855,0.0002150444,0.0004902696,0.0007378034,0.0004015801,0.0004698027],"domain_scores_gemma":[0.9986398,0.0001005466,0.0002641293,0.0006496385,0.000217265,0.0001286556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001199957,0.00009867171,0.007399112,0.0000531442,0.0000275439,0.000004746941,0.0004509176,0.002523023,0.9576051,0.000144621,0.03035338,0.001327728],"study_design_scores_gemma":[0.0006154987,0.0003401818,0.01059451,0.00002067155,0.00003438948,0.000002567523,0.0002219136,0.001825754,0.8678457,0.001695925,0.1167205,0.00008236083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.965507,0.001795964,0.01208133,0.0001151321,0.0008355374,0.0005998153,0.00002396596,0.0001556303,0.01888565],"genre_scores_gemma":[0.9794322,0.003432508,0.0008325165,0.0001663911,0.001140104,0.0001060216,0.001728542,0.00007142828,0.01309026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08975939,"threshold_uncertainty_score":0.9999483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01688824118099035,"score_gpt":0.2665214025367252,"score_spread":0.2496331613557348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}