{"id":"W4360828019","doi":"10.21203/rs.3.rs-2658142/v1","title":"Gain-of-function p53 R175H blocks apoptosis in a precursor model of ovarian high-grade serous carcinoma","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"London Health Sciences Foundation","keywords":"Biology; Spheroid; Apoptosis; Ovarian carcinoma; Missense mutation; Cancer research; Mutant; Cell biology; Ovarian cancer; Cell culture; Gene; Mutation; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001984192,0.0002848043,0.0003012223,0.0004377886,0.0001933667,0.0002448738,0.0002337453,0.000371899,0.001026938],"category_scores_gemma":[0.0001404793,0.0001443697,0.0003410439,0.0002144499,0.0002686078,0.0001672421,0.0001772558,0.0007160573,0.0002394053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003064207,"about_ca_system_score_gemma":0.0002762511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009144751,"about_ca_topic_score_gemma":0.001383307,"domain_scores_codex":[0.9998361,0.00003229152,0.00002056649,0.00002412515,0.00004882314,0.00003803485],"domain_scores_gemma":[0.9997818,0.00004060869,0.00005338126,0.0000343972,0.00001427618,0.00007556722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002147199,0.0001768714,0.0002547347,0.00002790688,0.000004945452,0.0001800729,0.00002291106,0.0001209146,0.9981294,0.0001148994,0.00004992605,0.0007025711],"study_design_scores_gemma":[0.00006143619,0.002584389,0.00453969,0.000007649362,0.00001909526,0.0004634676,0.00008272917,0.001723607,0.9887432,0.00006393742,0.001704693,0.000006090066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972459,0.000395865,0.001165893,0.00006539516,0.00003078982,0.00005894201,0.0003445502,0.0000690801,0.0006235708],"genre_scores_gemma":[0.9964697,0.0003993475,0.00109889,0.00003205403,0.000005459065,0.00004904446,0.0003641734,0.00001390012,0.001567322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001026938,"threshold_uncertainty_score":0.003435433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1240422202999307,"score_gpt":0.3825083522441972,"score_spread":0.2584661319442665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}