{"id":"W4360828052","doi":"10.1073/pnas.2222073120","title":"Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Canada Research Chairs","keywords":"Antibody-dependent cell-mediated cytotoxicity; Indoline; Gp41; Antibody; Cytotoxicity; Chemistry; Trimer; Entry inhibitor; Virology; Biology; Virus; Cell biology; Biochemistry; Viral entry; Stereochemistry; In vitro; Viral replication; Epitope; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009306097,0.0003340651,0.0001683329,0.0002058743,0.0001506684,0.0001912505,0.0003269195,0.0002094403,0.001464815],"category_scores_gemma":[0.00009099855,0.0001091102,0.0001469109,0.0001234727,0.0001211734,0.0001578186,0.0001891506,0.0003187991,0.0003747097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003109032,"about_ca_system_score_gemma":0.0001916687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002871868,"about_ca_topic_score_gemma":0.0008632647,"domain_scores_codex":[0.9999344,0.00001162954,0.000004652572,0.00001346729,0.00001810266,0.00001771135],"domain_scores_gemma":[0.999977,0.000003137061,0.000007282118,0.000002247034,0.000004787116,0.000005525912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002625156,0.0002116187,0.000265111,0.0003790246,0.00001815249,0.0002063858,0.00002938417,0.001951276,0.9682164,0.002028415,0.0006200399,0.02581179],"study_design_scores_gemma":[0.0001259036,0.001705978,0.0007476704,0.00002364942,0.00001639085,0.0003685433,0.00001862357,0.001895005,0.973038,0.0001689636,0.02187595,0.00001548115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9445474,0.01389249,0.01605333,0.000243002,0.0001001059,0.0004713094,0.000889106,0.0003517467,0.02345164],"genre_scores_gemma":[0.9768058,0.005370868,0.01106159,0.0001633793,0.00001916391,0.0001504326,0.0006587197,0.00001914682,0.005750795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001464815,"threshold_uncertainty_score":0.004900277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02775872957527141,"score_gpt":0.3005527187152593,"score_spread":0.2727939891399879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}