{"id":"W4360828195","doi":"10.1126/sciadv.adf7175","title":"Clinical PARP inhibitors allosterically induce PARP2 retention on DNA","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Allosteric regulation; PARP1; DNA damage; Poly ADP ribose polymerase; DNA; DNA repair; Chemistry; Cancer research; Biology; Cell biology; Biochemistry; Enzyme; Polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002251315,0.0003433206,0.0002721977,0.0001303031,0.0001643328,0.0003239077,0.000365156,0.0003271065,0.005784635],"category_scores_gemma":[0.0002883504,0.00017607,0.0002368384,0.0001795773,0.0002693389,0.0002552691,0.0001492172,0.0008645118,0.0009019325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002938507,"about_ca_system_score_gemma":0.0001708058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002284073,"about_ca_topic_score_gemma":0.0003990426,"domain_scores_codex":[0.9997417,0.00004708764,0.00001766807,0.00007587695,0.00007465059,0.00004310559],"domain_scores_gemma":[0.9998361,0.00003244311,0.00006303932,0.0000321213,0.00001626232,0.0000200578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003505743,0.0001392938,0.0002788705,0.00008416258,0.00001841372,0.00003776708,0.00001626034,0.0001960919,0.9921592,0.0003901304,0.0004076176,0.005921566],"study_design_scores_gemma":[0.00007259849,0.001090172,0.002728715,0.000005398508,0.00001819201,0.0003490042,0.00001280173,0.0007331552,0.9896691,0.0000956372,0.005218321,0.000006861669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750745,0.004759959,0.009542097,0.0003796713,0.0001331841,0.00009328586,0.0006925558,0.0004101151,0.008914649],"genre_scores_gemma":[0.9933807,0.000935419,0.002172747,0.0001540958,0.00001700745,0.00003839679,0.0005048467,0.00002472418,0.002772097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005784635,"threshold_uncertainty_score":0.01935154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08361955253947974,"score_gpt":0.4244328533604038,"score_spread":0.340813300820924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}