{"id":"W4360828195","doi":"10.1126/sciadv.adf7175","title":"Clinical PARP inhibitors allosterically induce PARP2 retention on DNA","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Allosteric regulation; PARP1; DNA damage; Poly ADP ribose polymerase; DNA; DNA repair; Chemistry; Cancer research; Biology; Cell biology; Biochemistry; Enzyme; Polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0015524,0.0001441119,0.0002548043,0.0002668325,0.0002427297,0.00004286166,0.0002464892,0.00007273386,0.00008923057],"category_scores_gemma":[0.0005421511,0.0001153344,0.0001119716,0.001980203,0.001040608,0.0005580647,0.00006559293,0.0002566976,0.000746143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000118823,"about_ca_system_score_gemma":0.0002794802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002093074,"about_ca_topic_score_gemma":0.000002224269,"domain_scores_codex":[0.9974213,0.00006184578,0.0004657847,0.0006436642,0.0009548223,0.0004525981],"domain_scores_gemma":[0.9988422,0.0001652279,0.0001612004,0.0004182333,0.0001615487,0.0002516171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0007341509,0.0003949597,0.08061602,0.00007980555,0.0000298654,0.0001367535,0.0004258278,0.0001294518,0.4406057,0.001133675,0.01205045,0.4636634],"study_design_scores_gemma":[0.004496463,0.004283285,0.3496581,0.001130479,0.0000503321,0.00006630116,0.00111326,0.000331995,0.3306926,0.008033481,0.2993374,0.0008063201],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846453,0.0001491468,0.00007105053,0.004510829,0.002194853,0.0003152335,0.000005888216,0.0003096835,0.007798008],"genre_scores_gemma":[0.9944038,0.0004147011,0.0008846877,0.002373945,0.0006632383,0.00004986307,0.0000108362,0.00001665643,0.001182286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.462857,"threshold_uncertainty_score":0.9590408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08361955253947974,"score_gpt":0.4244328533604038,"score_spread":0.340813300820924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}