{"id":"W4360852220","doi":"10.1038/s41698-023-00368-x","title":"Homologous recombination deficiency signatures in gastrointestinal and thoracic cancers correlate with platinum therapy duration","year":2023,"lang":"en","type":"article","venue":"npj Precision Oncology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Simon Fraser University; Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Pancreas Centre (Canada)","funders":"Canadian Institutes of Health Research; Vancouver Coastal Health Research Institute; Canada Research Chairs","keywords":"Loss of heterozygosity; Medicine; Haploinsufficiency; Germline; Internal medicine; Allele; Germline mutation; Oncology; Cancer research; Phenotype; Gene; Mutation; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003402739,0.00006883025,0.0002513581,0.0002892461,0.00008203831,0.0002848608,0.0001107292,0.0001770943,0.0009912235],"category_scores_gemma":[0.001425969,0.00008062732,0.0002258085,0.0003923407,0.0001235057,0.0001445457,0.0002102009,0.0002606748,0.0001412316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001596351,"about_ca_system_score_gemma":0.00009656724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005348111,"about_ca_topic_score_gemma":0.0009851299,"domain_scores_codex":[0.9998203,0.00003132176,0.00003257595,0.00005541281,0.00003379396,0.00002656901],"domain_scores_gemma":[0.9989001,0.000300419,0.0005278954,0.00007083483,0.00007314118,0.0001277038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001472253,0.00001826254,0.9720891,0.00004876823,0.0001024813,0.0001627022,0.00005233804,0.0003859898,0.009268893,0.00003709837,0.0002157764,0.01614625],"study_design_scores_gemma":[0.00001138115,0.0001813396,0.9974065,0.000005663634,0.00005034481,0.0006231208,0.00003069736,0.0003219397,0.000859882,0.00004103107,0.0004655117,0.000002542906],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997563,0.001154298,0.000197708,0.00003733116,0.000003521297,0.000006233733,0.000408759,0.000009199191,0.0006199073],"genre_scores_gemma":[0.9990098,0.0001731524,0.0001018342,0.00002273074,0.000003729509,0.000006087167,0.0004923158,0.000003487814,0.0001868162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009912235,"threshold_uncertainty_score":0.003315985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0145671136535303,"score_gpt":0.2978364870751457,"score_spread":0.2832693734216153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}