{"id":"W4360856474","doi":"10.3390/metabo13040467","title":"Therapy-Resistant Acute Myeloid Leukemia Stem Cells Are Resensitized to Venetoclax + Azacitidine by Targeting Fatty Acid Desaturases 1 and 2","year":2023,"lang":"en","type":"article","venue":"Metabolites","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Cancer Institute","keywords":"Venetoclax; Myeloid leukemia; Azacitidine; Cancer research; Fatty acid; Leukemia; Stem cell; Beta oxidation; Medicine; Pharmacology; Chemistry; Internal medicine; Biology; Biochemistry; Gene; Chronic lymphocytic leukemia; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00101417,0.0004785321,0.0009884473,0.0004674661,0.0003048858,0.0001519198,0.0002763064,0.0002059707,0.0001021554],"category_scores_gemma":[0.0002997142,0.0003801828,0.0001776188,0.001458557,0.0001869461,0.0001651937,0.000315117,0.0005536997,0.0003193795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005543609,"about_ca_system_score_gemma":0.0004151362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001584784,"about_ca_topic_score_gemma":0.000007212509,"domain_scores_codex":[0.9963509,0.0002906624,0.0005580725,0.0008570301,0.0008147457,0.001128619],"domain_scores_gemma":[0.9977029,0.0004864154,0.0001514954,0.0006581303,0.0003373381,0.0006637232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00120753,0.00001904107,0.001324438,0.00009940592,0.0003057601,0.0003982114,0.0004011539,0.00001079289,0.9301212,0.0000332719,0.05933791,0.006741211],"study_design_scores_gemma":[0.002583202,0.0002101534,0.009136028,0.0001203119,0.0001284209,0.00003339966,0.0009226367,0.0004145302,0.8991703,0.00003994305,0.08686358,0.0003774927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832566,0.01214433,0.00006827055,0.00201598,0.0001740034,0.001171838,0.0004889737,0.0004527954,0.0002272571],"genre_scores_gemma":[0.9778938,0.008195144,0.004912642,0.001882352,0.0005959313,0.0002131066,0.0003558047,0.0001917704,0.005759405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03095097,"threshold_uncertainty_score":0.999865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02440669952445526,"score_gpt":0.2840247969695758,"score_spread":0.2596180974451206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}