{"id":"W4360856474","doi":"10.3390/metabo13040467","title":"Therapy-Resistant Acute Myeloid Leukemia Stem Cells Are Resensitized to Venetoclax + Azacitidine by Targeting Fatty Acid Desaturases 1 and 2","year":2023,"lang":"en","type":"article","venue":"Metabolites","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Cancer Institute","keywords":"Venetoclax; Myeloid leukemia; Azacitidine; Cancer research; Fatty acid; Leukemia; Stem cell; Beta oxidation; Medicine; Pharmacology; Chemistry; Internal medicine; Biology; Biochemistry; Gene; Chronic lymphocytic leukemia; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008038288,0.0002188401,0.0003057139,0.0002142404,0.000134859,0.0003343733,0.0001275265,0.000139702,0.001729511],"category_scores_gemma":[0.0001002982,0.00009289011,0.0001547831,0.0001955812,0.0001408068,0.0001081075,0.0001588454,0.0004634824,0.0003528906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001816719,"about_ca_system_score_gemma":0.0001663906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000473286,"about_ca_topic_score_gemma":0.001468628,"domain_scores_codex":[0.9999412,0.000009214775,0.000004365976,0.00001521488,0.00001718632,0.00001280868],"domain_scores_gemma":[0.9999577,0.000007254757,0.00001251434,0.000006842638,0.000003575767,0.00001216961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003294608,0.00006816785,0.00130166,0.00005199,0.00001877115,0.0001044609,0.00002961578,0.0001871209,0.9830263,0.0001396885,0.0002337428,0.01450901],"study_design_scores_gemma":[0.0001307801,0.001651517,0.03040101,0.00002268842,0.00007086688,0.001304218,0.00007312035,0.001443663,0.9447348,0.0002297747,0.01992691,0.00001080485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936713,0.003317604,0.0009264162,0.0001016552,0.00002799313,0.0000355412,0.0003360312,0.0001328204,0.001450616],"genre_scores_gemma":[0.9939548,0.001658671,0.001223249,0.00007983117,0.00001482474,0.00002930021,0.0007822298,0.00001568885,0.002241496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001729511,"threshold_uncertainty_score":0.005785823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02440669952445526,"score_gpt":0.2840247969695758,"score_spread":0.2596180974451206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}