{"id":"W4360857826","doi":"10.3390/cells12070980","title":"S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"National Cancer Institute; National Institutes of Health; Instituto Nacional de Cancerología; School of Medicine, Boston University; Boston University; Mary Kay Foundation; American Cancer Society","keywords":"Triple-negative breast cancer; Phosphorylation; Cancer research; Protein kinase B; Breast cancer; Zebrafish; Biology; Cancer; Medicine; Cell biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003010462,0.00008907272,0.0001276245,0.00002863188,0.00006261737,0.00001109495,0.00005197052,0.00005652858,0.00001286232],"category_scores_gemma":[0.00007087045,0.0000654653,0.00003560046,0.0001787274,0.00006374738,0.000003474911,0.0000853682,0.00004262595,0.000006208168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004349431,"about_ca_system_score_gemma":0.00004424334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000251997,"about_ca_topic_score_gemma":0.0001056709,"domain_scores_codex":[0.9994234,0.00005205978,0.0001133996,0.0001863995,0.00008984419,0.0001349392],"domain_scores_gemma":[0.9995981,0.0000617671,0.00005832811,0.0001445376,0.00008753753,0.00004969635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006984094,0.000008499455,0.002261244,0.00001750819,0.00002774276,0.000001525807,0.000444209,0.0005318655,0.9929941,0.00002179564,0.0008381692,0.002783441],"study_design_scores_gemma":[0.0003282656,0.00001923505,0.04946057,0.00001709696,0.00002033189,0.000003039111,0.0002244479,0.0002346231,0.9486554,0.00004708636,0.0009055072,0.00008439992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998279,0.0004680773,0.0002244927,0.0003828331,0.0002941,0.0001771927,0.0001122088,0.000008574499,0.00005356342],"genre_scores_gemma":[0.9985599,0.0006425953,0.00006119187,0.0001862254,0.0002437427,0.00001655694,0.00002770751,0.0000112257,0.000250854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04719933,"threshold_uncertainty_score":0.2669597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01021454816532482,"score_gpt":0.2457247937967476,"score_spread":0.2355102456314228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}