{"id":"W4360946974","doi":"10.1038/s41467-023-37304-3","title":"An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer’s disease","year":2023,"lang":"en","type":"review","venue":"Nature Communications","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":166,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McGill University; University of British Columbia; Simon Fraser University; University of Victoria","funders":"Canadian Institutes of Health Research; University of Victoria","keywords":"Senescence; Microglia; Neurodegeneration; Inflammation; Neuroscience; Alzheimer's disease; Cognitive decline; Neuroinflammation; Oxidative stress; Disease; Medicine; Neuroglia; Aging brain; Brain aging; Pathology; Biology; Immunology; Dementia; Central nervous system; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009473333,0.001272112,0.001657695,0.002311213,0.0003417463,0.001110571,0.001364526,0.001795972,0.00213415],"category_scores_gemma":[0.0007927941,0.0003200465,0.0006647935,0.00135882,0.001316295,0.001974243,0.0008537848,0.002846111,0.001638096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001288354,"about_ca_system_score_gemma":0.001593546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001293636,"about_ca_topic_score_gemma":0.001993419,"domain_scores_codex":[0.999801,0.00004259946,0.00003185511,0.00003762384,0.00006511067,0.00002190748],"domain_scores_gemma":[0.9997244,0.0001057789,0.00004208412,0.000009287699,0.00008329606,0.0000350874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002023528,0.0001135463,0.0004545939,0.02542333,0.0001946934,0.0006102357,0.0001431887,0.0006696719,0.003210187,0.02632512,0.0502219,0.8924312],"study_design_scores_gemma":[0.00004891258,0.0002276205,0.002156411,0.006995124,0.0002232131,0.003383003,0.00015224,0.0003069507,0.0008132675,0.01772098,0.9679254,0.00004677551],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008517989,0.9984444,0.0001522424,0.0004693991,0.0002518649,0.000004900604,0.0000108416,0.000006303696,0.0005748955],"genre_scores_gemma":[0.0009253636,0.997852,0.0001657899,0.0003051511,0.0002553735,0.00001020003,0.00001876337,0.000001256777,0.000466079],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002311213,"threshold_uncertainty_score":0.009347737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1759350083907234,"score_gpt":0.4063813541810317,"score_spread":0.2304463457903083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}