{"id":"W4360960468","doi":"10.1016/j.molmet.2023.101713","title":"Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity","year":2023,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canada First Research Excellence Fund; Australian Government; Université Laval; Association pour la Recherche sur le Cancer","keywords":"Endocannabinoid system; Endocrinology; Internal medicine; Leptin; Lysophosphatidic acid; Orexin; Energy homeostasis; Hypothalamus; Biology; Neuropeptide Y receptor; Synaptic plasticity; Chemistry; Neuropeptide; Cell biology; Medicine; Receptor; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001738746,0.0003676947,0.0003659253,0.0003017448,0.0002165889,0.000282888,0.0002802481,0.0004234621,0.00142273],"category_scores_gemma":[0.00006645093,0.0002477255,0.0004635606,0.0001858425,0.0003806563,0.0002800504,0.0003670146,0.0009683486,0.0003440564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00041369,"about_ca_system_score_gemma":0.0002321198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006496537,"about_ca_topic_score_gemma":0.001476332,"domain_scores_codex":[0.9998342,0.00001258333,0.00001512371,0.0000392931,0.00004351129,0.00005530361],"domain_scores_gemma":[0.9999009,0.00000999332,0.00003126371,0.00001096089,0.00000959603,0.00003722116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001110405,0.00002214673,0.0001134177,0.00002311602,0.000003963793,0.00005151474,0.000008219861,0.00001331731,0.9993446,0.00003664936,0.00001349672,0.000258518],"study_design_scores_gemma":[0.00005112965,0.0004197898,0.01283218,0.00001300801,0.0000213835,0.0003471725,0.00005938308,0.0005204681,0.9844058,0.00005903193,0.001265132,0.000005584046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951305,0.001001544,0.001954489,0.0001487865,0.00005316085,0.0000355048,0.0004232273,0.00006963433,0.001183237],"genre_scores_gemma":[0.9893358,0.001378695,0.004297066,0.0001568071,0.00001968868,0.0001341521,0.0005126376,0.00005882855,0.004106233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00142273,"threshold_uncertainty_score":0.00475949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02982455416351203,"score_gpt":0.2853048206415216,"score_spread":0.2554802664780095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}