{"id":"W4360965054","doi":"10.1186/s40035-023-00347-z","title":"Modulating arousal to overcome gait impairments in Parkinson’s disease: how the noradrenergic system may act as a double-edged sword","year":2023,"lang":"en","type":"review","venue":"Translational Neurodegeneration","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Parkinsonfonden; Koninklijke Nederlandse Akademie van Wetenschappen; ZonMw; Michael J. Fox Foundation for Parkinson's Research","keywords":"Arousal; Locus coeruleus; Psychology; Neuroscience; Gait; Anxiety; Disease; Physical medicine and rehabilitation; Cognitive psychology; Medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003528045,0.0001864096,0.0002519668,0.000176507,0.0001627047,0.0007063053,0.0001418716,0.0002048277,0.000323442],"category_scores_gemma":[0.0008965574,0.00008343269,0.00017538,0.0001105375,0.0002836564,0.000284989,0.000327873,0.0003542745,0.00005638237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000196642,"about_ca_system_score_gemma":0.0001798086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008532396,"about_ca_topic_score_gemma":0.002225759,"domain_scores_codex":[0.9998716,0.00005852864,0.000009107037,0.00001802384,0.00001699704,0.00002574071],"domain_scores_gemma":[0.9998063,0.00004591148,0.0000664322,0.00001486646,0.00002506911,0.00004148006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.002909093,0.0009432473,0.5214252,0.0007515886,0.0007932364,0.001049254,0.002952926,0.00188797,0.1545365,0.003775543,0.001003693,0.3079719],"study_design_scores_gemma":[0.00005024713,0.00156444,0.9836422,0.0001592026,0.0001380813,0.0005935756,0.0008049277,0.002367396,0.005897202,0.002774549,0.001989003,0.0000192127],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9932716,0.002630609,0.00138718,0.0004321183,0.00002746445,0.00001652351,0.00003869558,0.00001135831,0.002184405],"genre_scores_gemma":[0.9982389,0.0008272238,0.0005845367,0.0001333414,0.00001616553,0.000006374981,0.00002047752,0.000002000723,0.0001709745],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0008532396,"threshold_uncertainty_score":0.001865804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07801084767150712,"score_gpt":0.3341606754027801,"score_spread":0.256149827731273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}