{"id":"W4360979922","doi":"10.1007/s43657-023-00100-6","title":"Hidden Genetic Regulation of Human Complex Traits via Brain Isoforms","year":2023,"lang":"en","type":"article","venue":"Phenomics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research","funders":"National Key Research and Development Program of China; Vetenskapsrådet; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Gene isoform; Focus (optics); Biology; Evolutionary biology; Computational biology; Neuroscience; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006020545,0.0003281526,0.0002550838,0.0008059008,0.0002066834,0.000397944,0.0002216289,0.0001823235,0.001218976],"category_scores_gemma":[0.00130278,0.0001756071,0.0003593567,0.0006341171,0.0005008039,0.0002114206,0.0004024183,0.0003221028,0.0001329613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001508322,"about_ca_system_score_gemma":0.0001158778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000873848,"about_ca_topic_score_gemma":0.001125269,"domain_scores_codex":[0.999447,0.000166083,0.00002823288,0.0002445995,0.0000764342,0.00003754859],"domain_scores_gemma":[0.9991832,0.0003789306,0.0002710301,0.0001058947,0.00003237975,0.00002851851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009306592,0.00007129153,0.6026663,0.000155639,0.0008570879,0.001215392,0.0006966953,0.002041799,0.3360535,0.004224913,0.0003712771,0.05071548],"study_design_scores_gemma":[0.00001386005,0.00006763788,0.9845499,0.00001105003,0.0001092245,0.0007814362,0.00006996567,0.003065838,0.007741802,0.003025673,0.0005477807,0.00001588498],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855105,0.0006078233,0.01222415,0.0001017853,0.000006598988,0.00001053973,0.0006619559,0.00005987475,0.0008167296],"genre_scores_gemma":[0.9949404,0.0002289643,0.004220028,0.00006210527,0.000009777059,0.00001512522,0.0002712626,0.00002290666,0.0002294872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001218976,"threshold_uncertainty_score":0.004077852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02911059751385826,"score_gpt":0.2829212469728643,"score_spread":0.2538106494590061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}