{"id":"W4360979922","doi":"10.1007/s43657-023-00100-6","title":"Hidden Genetic Regulation of Human Complex Traits via Brain Isoforms","year":2023,"lang":"en","type":"article","venue":"Phenomics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research","funders":"National Key Research and Development Program of China; Vetenskapsrådet; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Gene isoform; Focus (optics); Biology; Evolutionary biology; Computational biology; Neuroscience; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002326627,0.00009644782,0.0001637982,0.00005066202,0.00008027229,0.000005010233,0.0001438521,0.0001197855,0.00003589418],"category_scores_gemma":[0.00007537683,0.00009863058,0.00007475259,0.0001095028,0.00006000178,0.00000144223,0.00008013552,0.00003856244,0.00003112571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001502012,"about_ca_system_score_gemma":0.00002531264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002634591,"about_ca_topic_score_gemma":0.0000481155,"domain_scores_codex":[0.9991708,0.0000526374,0.0002978023,0.0002059606,0.00006050914,0.0002123256],"domain_scores_gemma":[0.9995291,0.00002446242,0.0001473816,0.0002027075,0.00005254319,0.00004376628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000009818841,0.00002438588,0.01555634,0.00001310924,0.00004571868,2.075937e-7,0.0001189397,0.000879748,0.9585177,0.0003860903,0.01197195,0.01247596],"study_design_scores_gemma":[0.0003791477,0.0001749653,0.9786569,0.000002733119,0.00001405962,0.000002887256,0.00007009879,0.00309911,0.00531578,0.006979065,0.005158142,0.0001470454],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942707,0.00004760873,0.004093804,0.0004715037,0.00005974494,0.0001240627,0.00002565353,0.0000177074,0.00088917],"genre_scores_gemma":[0.9952469,0.00003024171,0.003107586,0.0002132329,0.0001777161,0.00001025262,0.000458751,0.00001966744,0.0007356288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9631006,"threshold_uncertainty_score":0.4022038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02911059751385826,"score_gpt":0.2829212469728643,"score_spread":0.2538106494590061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}