{"id":"W4360989637","doi":"10.20944/preprints202303.0435.v1","title":"Disease-Specific α-Synuclein Seeding and Structural Properties in Lewy Body Disease and Multiple System Atrophy are Preserved in Formaldehyde-Fixed Paraffin-Embedded Human Brain","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; University Health Network; Toronto Western Hospital; Occupational Cancer Research Centre; University of Toronto","funders":"Temerty Faculty of Medicine, University of Toronto; University of Toronto","keywords":"Seeding; Synucleinopathies; Atrophy; Subtyping; Pathology; Alpha-synuclein; Biology; Chemistry; Disease; Computational biology; Medicine; Parkinson's disease; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004624735,0.0004255581,0.0001531445,0.0005129185,0.0001935449,0.0002661828,0.0001750881,0.0003062349,0.0006871517],"category_scores_gemma":[0.0003462294,0.0002234144,0.0001787753,0.0002020194,0.0003406584,0.0003425074,0.0002141663,0.0002384903,0.0002712361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001570117,"about_ca_system_score_gemma":0.0001424263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004297018,"about_ca_topic_score_gemma":0.001068678,"domain_scores_codex":[0.9998523,0.00002543669,0.00002462077,0.00004831074,0.00002861102,0.00002070368],"domain_scores_gemma":[0.9998072,0.00003712571,0.00006061199,0.00003591614,0.00003603286,0.000023108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0000770728,0.00001431718,0.00130861,0.00007642241,0.00001218829,0.0002260668,0.00005375927,0.00004549646,0.9966832,0.00005678349,0.00001720745,0.001428804],"study_design_scores_gemma":[0.00001291371,0.0004921125,0.09462159,0.00006404889,0.0001209087,0.005427637,0.000153218,0.001168565,0.8944617,0.0002417491,0.003218599,0.00001701838],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821466,0.0055919,0.01060556,0.00004445788,0.00002342665,0.00005977591,0.000336741,0.00008303108,0.001108614],"genre_scores_gemma":[0.9728688,0.00474949,0.01909489,0.0000748868,0.0000137909,0.0001195034,0.001059641,0.00006185321,0.001957176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006871517,"threshold_uncertainty_score":0.002445817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1619891148357026,"score_gpt":0.3233073553774318,"score_spread":0.1613182405417292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}