{"id":"W4360991388","doi":"10.21203/rs.3.rs-2729018/v1","title":"Microbiota-dependent expression of CTLA-4 by innate lymphoid cells restrains IFNγ dependent colitis","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Biotechnology and Biological Sciences Research Council; St. George's, University of London; Medical Research Council; King's College London; Wellcome Trust","keywords":"Innate lymphoid cell; Immunology; Innate immune system; Biology; Inflammatory bowel disease; Colitis; Microbiome; Inflammation; Acquired immune system; Homeostasis; CTLA-4; Immunity; Immune system; Population; Blockade; Gut flora; Cell biology; Disease; T cell; Medicine; Bioinformatics; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001299412,0.0003018754,0.000295952,0.0002329838,0.0001417316,0.000508662,0.0001438295,0.000400352,0.003664252],"category_scores_gemma":[0.0001674639,0.00015633,0.0003089469,0.000133012,0.000225136,0.0001920225,0.0003279587,0.001450232,0.001338472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002580753,"about_ca_system_score_gemma":0.000310533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003302982,"about_ca_topic_score_gemma":0.0004618787,"domain_scores_codex":[0.9998042,0.0000226536,0.00001010278,0.0000299683,0.00004597609,0.00008711169],"domain_scores_gemma":[0.9999185,0.000009978839,0.00001916552,0.00001375077,0.000008749529,0.00002988262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004317248,0.00005319898,0.0002811302,0.00003561923,0.000005605988,0.00009410354,0.00001323427,0.00007680397,0.9963308,0.0001788444,0.000206257,0.002292753],"study_design_scores_gemma":[0.0001275915,0.0004515132,0.0145195,0.00002242124,0.00003472311,0.0005155449,0.00014142,0.00183017,0.9747149,0.0007580788,0.00687584,0.000008240411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904478,0.001554431,0.00290675,0.0005453172,0.0002089619,0.00002294226,0.0006746106,0.0001819501,0.003457399],"genre_scores_gemma":[0.9897985,0.0006613584,0.001332521,0.0001591217,0.00004244316,0.00003313462,0.0006715635,0.00006513114,0.007236135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003664252,"threshold_uncertainty_score":0.01225817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05766734886308984,"score_gpt":0.3390181770187397,"score_spread":0.2813508281556499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}