{"id":"W4360994659","doi":"10.1093/genetics/iyad051","title":"Regulation of the hypertonic stress response by the 3′ mRNA cleavage and polyadenylation complex","year":2023,"lang":"en","type":"article","venue":"Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institutes of Health; University of Pittsburgh; National Institute of General Medical Sciences; Arizona State University; Northwestern University","keywords":"Polyadenylation; Biology; Mutant; Cell biology; Caenorhabditis elegans; Osmolyte; Cleavage factor; Cleavage and polyadenylation specificity factor; Terminator (solar); Downregulation and upregulation; Genetics; Gene expression; Molecular biology; Messenger RNA; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002441107,0.00005472538,0.00004771987,0.00001753113,0.0001190236,0.00001610018,0.0001444776,0.00005281256,0.000004022267],"category_scores_gemma":[0.00008169949,0.00003468801,0.00002773188,0.0001231378,0.0001061462,0.000001173964,0.0001300237,0.00004710688,0.000002426963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004902864,"about_ca_system_score_gemma":0.0000287658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001279109,"about_ca_topic_score_gemma":0.00003680344,"domain_scores_codex":[0.999375,0.0001347623,0.0001024142,0.0001162198,0.0001395383,0.0001320336],"domain_scores_gemma":[0.9995795,0.00003432654,0.00004320429,0.0002823507,0.00003319076,0.00002741828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007686203,0.000004869872,0.004213808,0.000004998175,0.000009284126,1.560624e-7,0.00003898853,0.000159078,0.9851382,0.00001156128,0.007793905,0.002548321],"study_design_scores_gemma":[0.0001729267,0.00006668315,0.4465405,0.000005481586,0.000004821797,0.000002941083,0.00009249928,0.002219162,0.5432688,0.00003586731,0.007546518,0.00004385497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979527,0.000468767,0.00006471876,0.001240317,0.00002807778,0.0001334541,0.00003134248,0.000004943151,0.00007570659],"genre_scores_gemma":[0.9977397,0.0002105923,0.0000507443,0.00008186124,0.00003520564,0.000004020544,0.00004069539,0.000009108171,0.001828015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4423267,"threshold_uncertainty_score":0.1414536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02027402620349055,"score_gpt":0.2753350105265311,"score_spread":0.2550609843230405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}