{"id":"W4361002984","doi":"10.21203/rs.3.rs-2702044/v1","title":"Translatome analysis of Tuberous Sclerosis Complex-1 patient-derived neural progenitor cells reveal rapamycin-dependent and independent alterations","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institutes of Health; Vetenskapsrådet; Wellcome Trust","keywords":"Tuberous sclerosis; Progenitor; Progenitor cell; Neuroscience; Neural stem cell; Biology; Medicine; Cell biology; Pathology; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002352239,0.0007143858,0.002098633,0.004552998,0.0005441503,0.0003835604,0.0008238184,0.0006743857,0.0004885481],"category_scores_gemma":[0.0003975078,0.0006844105,0.0009315495,0.003510845,0.0008319475,0.000180614,0.002303439,0.003381649,0.00008282458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006288082,"about_ca_system_score_gemma":0.0008669433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003004153,"about_ca_topic_score_gemma":0.001558561,"domain_scores_codex":[0.9877337,0.001723144,0.00161906,0.001928762,0.005295809,0.001699479],"domain_scores_gemma":[0.9929997,0.001059647,0.0003334779,0.002147061,0.002401235,0.001058834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001333449,0.001927261,0.0576186,0.004918769,0.00792077,0.0002592329,0.006403614,0.004177785,0.8998426,0.00009101905,0.003026465,0.01248044],"study_design_scores_gemma":[0.004398066,0.002932579,0.8846009,0.002212222,0.003067678,0.00006690883,0.00282993,0.03641568,0.06181796,0.0002943296,0.0001508975,0.001212853],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882593,0.001037448,0.0001665809,0.002005988,0.0003006256,0.005530126,0.00234466,0.0002452667,0.0001100524],"genre_scores_gemma":[0.9951873,0.0006268981,0.0009419609,0.00005148407,0.0002853071,0.0009465509,0.001429576,0.0001986291,0.0003322832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8380246,"threshold_uncertainty_score":0.9995607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2103420024405789,"score_gpt":0.4003605115263648,"score_spread":0.190018509085786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}