{"id":"W4361007123","doi":"10.1038/s41423-023-00989-z","title":"A T follicular helper cell origin for T regulatory type 1 cells","year":2023,"lang":"en","type":"article","venue":"Cellular and Molecular Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"CIHR Skin Research Training Centre; Praespero; Alberta Diabetes Foundation; Ministerio de Ciencia e Innovación; Generalitat de Catalunya; Centres de Recerca de Catalunya; Government of Canada; California State University, Chico; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Genome Canada; University of Michigan","keywords":"Cell biology; Biology; Downregulation and upregulation; BCL6; Reprogramming; Molecular biology; Progenitor cell; T cell; Chemistry; Cell; Immunology; Germinal center; B cell; Cancer research; Antibody; Stem cell; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001199186,0.0004868263,0.0002049668,0.0002281453,0.0003061065,0.0004294649,0.0002416536,0.0003522755,0.006337183],"category_scores_gemma":[0.0001250924,0.0001078378,0.0002435366,0.0001725971,0.0002661963,0.0002434001,0.0002690599,0.0007864014,0.002671348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002083645,"about_ca_system_score_gemma":0.0002194615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002075096,"about_ca_topic_score_gemma":0.0002723168,"domain_scores_codex":[0.9997939,0.00002790076,0.000009699704,0.00008890824,0.00004282543,0.00003685922],"domain_scores_gemma":[0.9998841,0.00001796784,0.00002896351,0.00001892728,0.00002040217,0.00002962921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008382806,0.00002415895,0.0007748294,0.0001119591,0.000007518331,0.0001823628,0.00004790694,0.00003550204,0.9869556,0.0005029372,0.0003565148,0.01091703],"study_design_scores_gemma":[0.00005557819,0.0006955548,0.01016882,0.0000511859,0.00007557589,0.004153498,0.0001681984,0.001118389,0.9096307,0.0007810781,0.07308272,0.00001867643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.909298,0.01361728,0.04226317,0.0006924946,0.0006341106,0.0002379201,0.001456067,0.001314449,0.03048644],"genre_scores_gemma":[0.9728334,0.002547454,0.006962558,0.0003251225,0.0001570923,0.0000890169,0.0008349955,0.0001065934,0.01614372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006337183,"threshold_uncertainty_score":0.02120006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01034553503308833,"score_gpt":0.2239772118756683,"score_spread":0.21363167684258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}