{"id":"W4361007123","doi":"10.1038/s41423-023-00989-z","title":"A T follicular helper cell origin for T regulatory type 1 cells","year":2023,"lang":"en","type":"article","venue":"Cellular and Molecular Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"CIHR Skin Research Training Centre; Praespero; Alberta Diabetes Foundation; Ministerio de Ciencia e Innovación; Generalitat de Catalunya; Centres de Recerca de Catalunya; Government of Canada; California State University, Chico; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Genome Canada; University of Michigan","keywords":"Cell biology; Biology; Downregulation and upregulation; BCL6; Reprogramming; Molecular biology; Progenitor cell; T cell; Chemistry; Cell; Immunology; Germinal center; B cell; Cancer research; Antibody; Stem cell; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002596392,0.0002677819,0.0003342181,0.0002721234,0.0002658931,0.00002503514,0.0001830541,0.0004477105,0.0004311528],"category_scores_gemma":[0.00004287272,0.0002647291,0.000191028,0.0002845091,0.0001937516,0.00007789883,0.0001152875,0.0002902889,0.001899829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003733108,"about_ca_system_score_gemma":0.0000590704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002577916,"about_ca_topic_score_gemma":9.760245e-7,"domain_scores_codex":[0.9984425,0.0001689969,0.000321391,0.0004811434,0.00003868645,0.0005472683],"domain_scores_gemma":[0.9991964,0.00008518608,0.0001074991,0.0004474087,0.0001331985,0.00003028833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002316493,0.00005967509,0.00002166394,0.0000345445,0.0001937559,0.00001883605,0.000184874,0.00001241525,0.973647,0.001309984,0.02340133,0.0008842475],"study_design_scores_gemma":[0.001084223,0.0002528421,0.00007510784,0.000008620033,0.0000546696,0.00002601078,0.0002209791,0.00002928518,0.6047565,0.0001416149,0.3931595,0.0001905844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698388,0.01639578,0.00326249,0.0002765069,0.007760551,0.0006126559,0.000008544848,0.0003196924,0.001524996],"genre_scores_gemma":[0.9610972,0.0006130235,0.0001188796,0.0004950549,0.00004160497,0.0000906541,0.0006270588,0.0000656507,0.03685085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3697582,"threshold_uncertainty_score":0.9999805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01034553503308833,"score_gpt":0.2239772118756683,"score_spread":0.21363167684258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}