{"id":"W4361010814","doi":"10.1016/j.jtct.2023.03.024","title":"Effect of Autograft CD34+ Dose on Outcome in Pediatric Patients Undergoing Autologous Hematopoietic Stem Cell Transplant for Central Nervous System Tumors","year":2023,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; SickKids Foundation; Hospital for Sick Children; BC Children's Hospital; University of Toronto","funders":"Cancer Moonshot; National Institute of Allergy and Infectious Diseases; Office of Naval Research; Pharmacyclics; Takeda Oncology; Health Resources and Services Administration; National Institutes of Health; MorphoSys; Legend Biotech; Sangamo Therapeutics; Astellas Pharma; Adaptive Biotechnologies; Kiadis Pharma; bluebird bio; TG Therapeutics; Jazz Pharmaceuticals; StemCyte; BeiGene; HistoGenetics; Atara Biotherapeutics; CareDx; Actinium Pharmaceuticals; National Cancer Institute; Gilead Sciences; Swedish Orphan Biovitrum; Omeros Corporation; Vertex Pharmaceuticals; Leukemia and Lymphoma Society; Moonshot Research and Development Program; Sanofi; GlaxoSmithKline; Incyte; Pfizer; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; CSL Behring; Bristol-Myers Squibb; AstraZeneca; Amgen; Mallinckrodt Pharmaceuticals; Astellas Pharma US","keywords":"Medicine; Quartile; Proportional hazards model; CD34; Hematopoietic stem cell transplantation; Autologous stem-cell transplantation; Oncology; Internal medicine; Transplantation; Surgery; Retrospective cohort study; Clinical endpoint; Stem cell; Clinical trial; Confidence interval; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002149901,0.0002271338,0.00046194,0.0002843876,0.00005918825,0.00001187504,0.00004922245,0.00009297876,0.000003913925],"category_scores_gemma":[0.000001219938,0.0001698284,0.0001568763,0.0002609551,0.00001912036,0.0000308914,0.000001763118,0.00008026438,0.000007938743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004580945,"about_ca_system_score_gemma":0.00002662312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002263397,"about_ca_topic_score_gemma":0.000008044323,"domain_scores_codex":[0.9986345,0.0001158115,0.0004353295,0.0002781831,0.000223996,0.0003122109],"domain_scores_gemma":[0.9992764,0.0003639572,0.0001060926,0.0001287886,0.00002063923,0.0001041276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00411661,0.0008276537,0.9649557,0.01000616,0.00009859101,0.0006729353,0.005557293,0.0004578602,0.004313831,0.0002577055,0.00001059088,0.008725011],"study_design_scores_gemma":[0.04610246,0.007851198,0.7352302,0.0008094492,0.0007072333,0.0000464016,0.0003664961,0.001871727,0.2065744,0.00001740228,0.00001201363,0.0004110015],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976295,0.0003827021,0.0001133656,0.00004735247,0.0001379764,0.001445794,0.00007038188,0.0001052046,0.00006777128],"genre_scores_gemma":[0.9984442,0.001000637,0.00001713964,0.00002777598,0.00002119304,0.0001406354,0.0002941348,0.00003197594,0.00002233528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2297256,"threshold_uncertainty_score":0.69254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01324987074449015,"score_gpt":0.2514878160864732,"score_spread":0.2382379453419831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}