{"id":"W4361029842","doi":"10.1016/j.jaccao.2022.10.017","title":"RBL2 Regulates Cardiac Sensitivity to Anthracycline Chemotherapy","year":2023,"lang":"et","type":"article","venue":"JACC CardioOncology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Canadian Institutes of Health Research; Abbott Laboratories","keywords":"Anthracycline; Chemotherapy; Sensitivity (control systems); Internal medicine; Medicine; Cancer; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001501529,0.0002317664,0.0001859204,0.000285263,0.000146963,0.0004003173,0.0001594352,0.0002869331,0.001340232],"category_scores_gemma":[0.000158362,0.0001403162,0.0001916243,0.0001568755,0.0002025707,0.00009635963,0.0001766429,0.0003870084,0.000506769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003341922,"about_ca_system_score_gemma":0.0001359511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006740547,"about_ca_topic_score_gemma":0.00109629,"domain_scores_codex":[0.9998589,0.00002191408,0.000009139634,0.00003853534,0.00004102531,0.00003053237],"domain_scores_gemma":[0.9998424,0.00001313317,0.00008681868,0.000008626476,0.00001447371,0.00003456021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006615309,0.00007984443,0.01927502,0.00006556696,0.00003536445,0.0004438546,0.00005937033,0.0001814758,0.972346,0.0002495549,0.0005247184,0.006077787],"study_design_scores_gemma":[0.0002430989,0.0007453137,0.5054047,0.00005698187,0.0002406836,0.004796012,0.0003027495,0.004746103,0.4629972,0.0003621983,0.02005296,0.0000519567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926415,0.003704109,0.0009038757,0.0001816698,0.00002469207,0.00001415625,0.000459933,0.0001158394,0.001954212],"genre_scores_gemma":[0.9971008,0.0006246689,0.0002326181,0.00006924805,0.00001236373,0.000009357263,0.0003305568,0.00001813007,0.001602328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001340232,"threshold_uncertainty_score":0.004483521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02316110421504399,"score_gpt":0.3184980846136502,"score_spread":0.2953369803986062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}