{"id":"W4361029842","doi":"10.1016/j.jaccao.2022.10.017","title":"RBL2 Regulates Cardiac Sensitivity to Anthracycline Chemotherapy","year":2023,"lang":"et","type":"article","venue":"JACC CardioOncology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Canadian Institutes of Health Research; Abbott Laboratories","keywords":"Anthracycline; Chemotherapy; Sensitivity (control systems); Internal medicine; Medicine; Cancer; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002928619,0.0007336903,0.002468365,0.0006606491,0.0003189018,0.00007548355,0.0002191462,0.001162385,0.0002204462],"category_scores_gemma":[0.0006538008,0.0007826701,0.001294392,0.002062115,0.0003304108,0.0001743746,0.0002310111,0.0008453188,0.00254669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008289993,"about_ca_system_score_gemma":0.0005878115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002667661,"about_ca_topic_score_gemma":0.00007791326,"domain_scores_codex":[0.9946923,0.0009483253,0.0007643286,0.001342851,0.0008032065,0.001448973],"domain_scores_gemma":[0.9961775,0.001038266,0.0002560003,0.001391171,0.000425711,0.0007113498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009079172,0.0001985032,0.004062238,0.0002486399,0.001953471,0.0008147536,0.003112181,0.0005824223,0.7435297,0.0001127261,0.1501106,0.09436682],"study_design_scores_gemma":[0.004573301,0.001032493,0.08548369,0.0002760877,0.0007068609,0.0002694502,0.001918267,0.000640203,0.5004756,0.0001674399,0.4034828,0.0009737114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9439334,0.0007929573,0.0004403379,0.03532466,0.005976861,0.002393253,0.0003527103,0.0007989989,0.009986857],"genre_scores_gemma":[0.9740387,0.003193684,0.0003318422,0.00622804,0.007765232,0.0001436862,0.0003949113,0.0002087157,0.007695241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2533722,"threshold_uncertainty_score":0.9994624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02316110421504399,"score_gpt":0.3184980846136502,"score_spread":0.2953369803986062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}