{"id":"W4361191279","doi":"10.1128/aac.01600-22","title":"The Natural Stilbenoid (–)-Hopeaphenol Inhibits HIV Transcription by Targeting Both PKC and NF-κB Signaling and Cyclin-Dependent Kinase 9","year":2023,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Alliance for Accelerating Excellence in Science in Africa; African Academy of Sciences; Ben Franklin Technology Partners of Northeastern Pennsylvania; Canadian Institutes of Health Research; Department of Education and Training; Simon Fraser University; Wellcome Trust; Griffith University; New Partnership for Africa's Development; Australian Research Council; Pennsylvania Department of Community and Economic Development; Fred J. Brotherton Charitable Foundation; Christian R. and Mary F. Lindback Foundation","keywords":"Kinase; Protein kinase C; Signal transduction; Human immunodeficiency virus (HIV); Transcription (linguistics); Transcription factor; Cancer research; Biology; Chemistry; Virology; Cell biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004710769,0.000287172,0.0002429162,0.00006001984,0.00101318,0.0001737463,0.000139439,0.0001699389,0.00008039033],"category_scores_gemma":[0.00001004206,0.0002212469,0.00006202951,0.0001426539,0.0003049661,0.0001490735,0.00007624592,0.0004315851,0.00001269773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000190679,"about_ca_system_score_gemma":0.00001662221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000268037,"about_ca_topic_score_gemma":0.000009450156,"domain_scores_codex":[0.9984961,0.0001583869,0.0003013772,0.0004404513,0.000122362,0.0004813261],"domain_scores_gemma":[0.9994854,0.0001143086,0.0001173567,0.00009294463,0.00003953547,0.0001504448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003161161,0.0001155882,0.009831036,0.00005988001,0.0001701092,0.00002171046,0.001064259,0.000006504491,0.9144605,0.00006182743,0.05366841,0.02022401],"study_design_scores_gemma":[0.007955624,0.0001873754,0.01379071,0.0001118478,0.0001735594,0.000056006,0.001023225,0.003680218,0.5578003,0.0002579878,0.4139971,0.0009660259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928969,0.001256005,0.00003823822,0.004562998,0.0005963735,0.0003474082,0.0001028174,0.00008542664,0.0001138389],"genre_scores_gemma":[0.9793178,0.01360931,0.00005213719,0.005411016,0.0001900036,0.000008873347,0.00007421206,0.00003831292,0.001298383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3603287,"threshold_uncertainty_score":0.9022188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03870535954623209,"score_gpt":0.3399781606213086,"score_spread":0.3012728010750765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}