{"id":"W4361191279","doi":"10.1128/aac.01600-22","title":"The Natural Stilbenoid (–)-Hopeaphenol Inhibits HIV Transcription by Targeting Both PKC and NF-κB Signaling and Cyclin-Dependent Kinase 9","year":2023,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Alliance for Accelerating Excellence in Science in Africa; African Academy of Sciences; Ben Franklin Technology Partners of Northeastern Pennsylvania; Canadian Institutes of Health Research; Department of Education and Training; Simon Fraser University; Wellcome Trust; Griffith University; New Partnership for Africa's Development; Australian Research Council; Pennsylvania Department of Community and Economic Development; Fred J. Brotherton Charitable Foundation; Christian R. and Mary F. Lindback Foundation","keywords":"Kinase; Protein kinase C; Signal transduction; Human immunodeficiency virus (HIV); Transcription (linguistics); Transcription factor; Cancer research; Biology; Chemistry; Virology; Cell biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009516921,0.0003318169,0.0001925851,0.0003770052,0.0001517684,0.0002401567,0.0001303797,0.0001414154,0.00261544],"category_scores_gemma":[0.00007551893,0.0001197373,0.0002746143,0.0001958922,0.0001541514,0.0002122718,0.0001865859,0.0003957728,0.0003326284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001510195,"about_ca_system_score_gemma":0.000231516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003432064,"about_ca_topic_score_gemma":0.001239654,"domain_scores_codex":[0.9999483,0.000007983248,0.0000048652,0.000009665213,0.00001451849,0.00001460133],"domain_scores_gemma":[0.9999585,0.00000919891,0.0000103695,0.000005157759,0.000005695078,0.00001103894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002479991,0.00009385456,0.0004098549,0.0001036617,0.00001273662,0.00005333594,0.00001144826,0.0002559861,0.9910618,0.0001762417,0.00007970895,0.007493332],"study_design_scores_gemma":[0.00005768,0.001789802,0.004427949,0.00002099643,0.00002935934,0.0002708776,0.00003229879,0.0004658681,0.9880783,0.0001133903,0.004706623,0.000006883101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845932,0.004479932,0.003706836,0.0001703292,0.0000408163,0.0001343558,0.001216187,0.00007569437,0.005582602],"genre_scores_gemma":[0.9892538,0.002854699,0.002816011,0.00008401846,0.00001362075,0.00003143915,0.0007487558,0.000007062851,0.004190565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00261544,"threshold_uncertainty_score":0.008749545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03870535954623209,"score_gpt":0.3399781606213086,"score_spread":0.3012728010750765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}