{"id":"W4361197222","doi":"10.33393/dti.2008.1332","title":"Recent Advancements in Targeted Delivery of Therapeutic Molecules in Neurodegenerative Disease–-Spinocerebellar Ataxia–-Opportunities and Challenges","year":2008,"lang":"en","type":"article","venue":"Drug Target Insights","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Faculty of Medicine, McGill University; McGill University","keywords":"Medicine; Spinocerebellar ataxia; Disease; Neuroscience; Bioinformatics; Intensive care medicine; Pathology; Psychology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006249222,0.0001749451,0.0002164147,0.0001305526,0.00004949624,0.000003450876,0.00009617448,0.0000815137,0.00003606907],"category_scores_gemma":[0.00002788195,0.0001646322,0.00003697023,0.0000838833,0.0001275432,0.00001019327,0.00006528459,0.00008431013,0.000001808543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001220288,"about_ca_system_score_gemma":0.00008845803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001570912,"about_ca_topic_score_gemma":0.0001705743,"domain_scores_codex":[0.9988278,0.0002306394,0.0002787839,0.0003646353,0.0001119903,0.00018613],"domain_scores_gemma":[0.9995219,0.00001498536,0.00008694184,0.0002177179,0.00007424068,0.00008427262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003877595,0.001905546,0.05574913,0.0004355595,0.0002481268,0.0009983339,0.01062187,0.002855932,0.8863914,0.005949383,0.002273802,0.02869334],"study_design_scores_gemma":[0.003723931,0.0006206913,0.06284358,0.00006410988,0.00002724225,0.00003133303,0.001358622,0.0006791157,0.3234226,0.00118995,0.6051939,0.0008449393],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9068847,0.0916994,0.0000789734,0.0003206268,0.0002163144,0.0002146489,0.00002676714,0.000007072641,0.0005515213],"genre_scores_gemma":[0.8112026,0.1874543,0.0003651109,0.0004173036,0.00005721032,0.00002926728,0.0001939475,0.00001684308,0.0002634399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6029201,"threshold_uncertainty_score":0.6713507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04846771950011428,"score_gpt":0.2384463568752153,"score_spread":0.189978637375101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}