{"id":"W4361199136","doi":"10.1002/bit.28387","title":"A CHO stable pool production platform for rapid clinical development of trimeric SARS‐CoV‐2 spike subunit vaccine antigens","year":2023,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; National Research Council Canada","funders":"","keywords":"Chinese hamster ovary cell; Biology; Computational biology; Protein subunit; Pandemic; Recombinant DNA; Productivity; Virology; Biotechnology; Coronavirus disease 2019 (COVID-19); Cell culture; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002363969,0.0001413451,0.0001941476,0.0001557605,0.0001101139,0.000006910655,0.00009871631,0.0003393531,0.000003024983],"category_scores_gemma":[0.0001082819,0.0001281727,0.00007232272,0.0002523187,0.00005180996,0.000005842699,0.0001110684,0.00009314805,0.000003332665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006940481,"about_ca_system_score_gemma":0.0000511129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002856711,"about_ca_topic_score_gemma":0.000006710346,"domain_scores_codex":[0.9990507,0.00000819363,0.0003173473,0.0003226587,0.0000492724,0.000251869],"domain_scores_gemma":[0.9995994,0.00001086042,0.00008409411,0.000218196,0.00004797529,0.00003945194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001100775,0.0000528309,0.001054833,0.00008752765,0.0001032508,8.418072e-7,0.00001437795,0.00008104067,0.9694911,0.0000376105,0.002005779,0.02696072],"study_design_scores_gemma":[0.000504675,0.0003468001,0.002479466,0.00002590755,0.0000201314,0.00000872374,0.00004140132,0.000509373,0.9355403,0.00002097163,0.06034315,0.0001591239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916978,0.0009077698,0.006275213,0.0001718853,0.0004370389,0.0003691436,0.0000165917,0.0001144053,0.00001016709],"genre_scores_gemma":[0.9960597,0.001335936,0.002145022,0.0000283995,0.0001480099,0.00006771583,0.00009229895,0.00001986633,0.0001030456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05833737,"threshold_uncertainty_score":0.5226729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03302785961398672,"score_gpt":0.3034733386498623,"score_spread":0.2704454790358756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}