{"id":"W4361199136","doi":"10.1002/bit.28387","title":"A CHO stable pool production platform for rapid clinical development of trimeric SARS‐CoV‐2 spike subunit vaccine antigens","year":2023,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; National Research Council Canada","funders":"","keywords":"Chinese hamster ovary cell; Biology; Computational biology; Protein subunit; Pandemic; Recombinant DNA; Productivity; Virology; Biotechnology; Coronavirus disease 2019 (COVID-19); Cell culture; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009851881,0.0005155691,0.0004002948,0.0006154062,0.0003270919,0.0006285839,0.0003911641,0.0005413727,0.001916354],"category_scores_gemma":[0.0004343112,0.0002376498,0.0004896611,0.0003502951,0.0002535501,0.0003826965,0.0004621165,0.000626187,0.001021533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003303986,"about_ca_system_score_gemma":0.0003610694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004007921,"about_ca_topic_score_gemma":0.0005577474,"domain_scores_codex":[0.9995022,0.0001115,0.000054457,0.00009193926,0.0002000185,0.00003982286],"domain_scores_gemma":[0.9997781,0.00003613717,0.00006243659,0.0000440255,0.00004730063,0.00003200954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008678073,0.00002782011,0.0001090544,0.00004007567,0.000008785011,0.00004007842,0.000019125,0.00008111503,0.9963031,0.00009802965,0.0001260293,0.003060066],"study_design_scores_gemma":[0.00005663326,0.001234427,0.00224568,0.00001609831,0.00006445106,0.0004431619,0.00002312725,0.001609359,0.9843072,0.0001003524,0.009878938,0.00002049443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7610082,0.003862336,0.2188074,0.0005748383,0.0002478933,0.001829555,0.004851625,0.001581276,0.00723674],"genre_scores_gemma":[0.762726,0.003156351,0.2156901,0.0003293271,0.00007257866,0.001384898,0.008688965,0.0003560145,0.007595676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001916354,"threshold_uncertainty_score":0.006410837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03302785961398672,"score_gpt":0.3034733386498623,"score_spread":0.2704454790358756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}