{"id":"W4361200268","doi":"10.22203/ecm.v045a07","title":"Ex vivo intervertebral disc cultures: degeneration-induction methods and their implications for clinical translation","year":2023,"lang":"en","type":"article","venue":"European Cells and Materials","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Arthritis Society; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Dutch Arthritis Society; National Science Foundation","keywords":"Ex vivo; Degeneration (medical); Translation (biology); Intervertebral disc; In vivo; Medicine; Pathology; Anatomy; Biology; Biotechnology; Messenger RNA; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000814199,0.0001151313,0.000242714,0.00005264518,0.00008759791,0.00005170548,0.0000392015,0.00005442596,0.0000789835],"category_scores_gemma":[0.00005865884,0.00007865682,0.00007168442,0.00005785413,0.00005911796,0.00009068099,0.00003473384,0.00004484951,0.00002540069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004377825,"about_ca_system_score_gemma":0.000007954146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004143205,"about_ca_topic_score_gemma":0.000002685221,"domain_scores_codex":[0.9989103,0.0002979971,0.000374511,0.0002677259,0.00002073894,0.0001287216],"domain_scores_gemma":[0.9996487,0.00002744283,0.00007257342,0.0001381666,0.00004079334,0.00007230186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002351226,0.00002913942,0.00005771201,0.00006482113,0.00002568803,8.394177e-7,0.0003682168,2.295969e-7,0.9544492,0.0004394897,0.009106666,0.03543454],"study_design_scores_gemma":[0.002284531,0.001031035,0.1890739,0.0001028133,0.0001694495,0.00007540624,0.0004505126,0.000203971,0.7621185,0.0009806363,0.04322407,0.000285194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739725,0.0002575141,0.02118899,0.001894952,0.0007647743,0.0005209553,0.0001624092,0.0001071288,0.001130759],"genre_scores_gemma":[0.9769427,0.001474453,0.01756397,0.0007679241,0.0009288783,0.00004181167,0.0004146711,0.00004920538,0.001816376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1923307,"threshold_uncertainty_score":0.3207532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1406787003259714,"score_gpt":0.4381441104635686,"score_spread":0.2974654101375972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}