{"id":"W4361201146","doi":"10.1016/j.jtct.2023.03.027","title":"HLA Class I Genotype Is Associated with Relapse Risk after Allogeneic Stem Cell Transplantation for NPM1-Mutated Acute Myeloid Leukemia","year":2023,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Office of Naval Research; Legend Biotech; Sanofi Genzyme; Takeda Oncology; Genentech; Health Resources and Services Administration; MorphoSys; Astellas Pharma; Adaptive Biotechnologies; Kiadis Pharma; bluebird bio; TG Therapeutics; Omeros Corporation; Vertex Pharmaceuticals; Medical College of Wisconsin; StemCyte; CSL Behring; St. Jude Children's Research Hospital; HistoGenetics; Atara Biotherapeutics; CareDx; Actinium Pharmaceuticals; Daiichi Sankyo Europe; National Cancer Institute; Servier; Gilead Sciences; AbbVie; Sanofi; GlaxoSmithKline; Bristol-Myers Squibb; Pharmacyclics; Agios Pharmaceuticals; Mallinckrodt Pharmaceuticals; Astellas Pharma US; Amgen; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Moderna; Incyte; Pfizer; Medac; Jazz Pharmaceuticals; Be The Match Foundation","keywords":"NPM1; Hazard ratio; Cumulative incidence; Internal medicine; Oncology; Hematopoietic stem cell transplantation; Transplantation; Myeloid leukemia; Medicine; Proportional hazards model; Human leukocyte antigen; Immunology; Genotype; Leukemia; Myeloid; Gastroenterology; Confidence interval; Biology; Genetics; Antigen; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004933822,0.0003614399,0.0004325777,0.0002978879,0.0002394167,0.00005581982,0.0001202913,0.0003066711,0.000106766],"category_scores_gemma":[0.00000282159,0.0002930839,0.0001478452,0.000628147,0.0001116148,0.0001528666,0.000004763775,0.0003831065,0.00007397475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000206763,"about_ca_system_score_gemma":0.0002884637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006088992,"about_ca_topic_score_gemma":0.00004858722,"domain_scores_codex":[0.9977834,0.0001877293,0.0004074026,0.0005768465,0.0004889964,0.0005556207],"domain_scores_gemma":[0.9989281,0.0002259926,0.0001508818,0.0002646063,0.0001985444,0.0002318955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.05056844,0.0003002976,0.02182437,0.001284924,0.002721303,0.003120746,0.02972267,0.0003379858,0.8577089,0.00006260019,0.001452234,0.03089558],"study_design_scores_gemma":[0.04391399,0.003083611,0.1048431,0.0003463986,0.002522788,0.0002859015,0.000870007,0.009927394,0.8293226,0.0001704219,0.003592976,0.001120844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990104,0.0006647875,0.005794307,0.0003947257,0.00007621559,0.001534916,0.0009065068,0.0002821982,0.0002423125],"genre_scores_gemma":[0.9587454,0.03212529,0.0003636423,0.0007014049,0.0000632793,0.0002902332,0.003659627,0.0001196758,0.003931443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0830187,"threshold_uncertainty_score":0.9999521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01598363930390024,"score_gpt":0.2546206635783839,"score_spread":0.2386370242744837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}