{"id":"W4361201146","doi":"10.1016/j.jtct.2023.03.027","title":"HLA Class I Genotype Is Associated with Relapse Risk after Allogeneic Stem Cell Transplantation for NPM1-Mutated Acute Myeloid Leukemia","year":2023,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Office of Naval Research; Legend Biotech; Sanofi Genzyme; Takeda Oncology; Genentech; Health Resources and Services Administration; MorphoSys; Astellas Pharma; Adaptive Biotechnologies; Kiadis Pharma; bluebird bio; TG Therapeutics; Omeros Corporation; Vertex Pharmaceuticals; Medical College of Wisconsin; StemCyte; CSL Behring; St. Jude Children's Research Hospital; HistoGenetics; Atara Biotherapeutics; CareDx; Actinium Pharmaceuticals; Daiichi Sankyo Europe; National Cancer Institute; Servier; Gilead Sciences; AbbVie; Sanofi; GlaxoSmithKline; Bristol-Myers Squibb; Pharmacyclics; Agios Pharmaceuticals; Mallinckrodt Pharmaceuticals; Astellas Pharma US; Amgen; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Moderna; Incyte; Pfizer; Medac; Jazz Pharmaceuticals; Be The Match Foundation","keywords":"NPM1; Hazard ratio; Cumulative incidence; Internal medicine; Oncology; Hematopoietic stem cell transplantation; Transplantation; Myeloid leukemia; Medicine; Proportional hazards model; Human leukocyte antigen; Immunology; Genotype; Leukemia; Myeloid; Gastroenterology; Confidence interval; Biology; Genetics; Antigen; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002638097,0.0001748107,0.0002151694,0.0003028642,0.0002590063,0.0004259687,0.0002865728,0.0003384463,0.002252979],"category_scores_gemma":[0.001924036,0.00009001236,0.0003135889,0.0004729924,0.0002168788,0.0002296245,0.0002129229,0.0005370168,0.0003332508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001506197,"about_ca_system_score_gemma":0.0001725544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007142986,"about_ca_topic_score_gemma":0.0007775238,"domain_scores_codex":[0.999774,0.0000751235,0.00002377299,0.00003702725,0.00003392799,0.0000561177],"domain_scores_gemma":[0.998577,0.0003243477,0.0007397683,0.00006268942,0.00005594877,0.0002402709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005851869,0.00006698054,0.9924701,0.000007056614,0.00006470744,0.0003178389,0.00004641142,0.00008700591,0.003139487,0.00003154244,0.0001046294,0.003079075],"study_design_scores_gemma":[0.00001220809,0.0002014619,0.9970778,0.00000636583,0.00006233295,0.001247237,0.0001681888,0.000432939,0.000466138,0.00009163994,0.0002284677,0.000005175955],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994721,0.0001297972,0.00004637239,0.00003398486,0.000007538508,0.000001249048,0.00002805852,0.000002242393,0.0002787052],"genre_scores_gemma":[0.9997255,0.00003640446,0.00002622129,0.00001886241,0.00001000954,0.000001137947,0.00004095491,0.000002092474,0.0001387214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002252979,"threshold_uncertainty_score":0.007536948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01598363930390024,"score_gpt":0.2546206635783839,"score_spread":0.2386370242744837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}