{"id":"W4361201958","doi":"10.1111/cts.13515","title":"Relative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling","year":2023,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"Genentech; F. Hoffmann-La Roche","keywords":"Alectinib; Capsule; Cmax; Medicine; Bioavailability; Crossover study; Venipuncture; Pharmacology; Anesthesia; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002506089,0.00007556032,0.0003025124,0.0001400898,0.0001000992,0.000007088128,0.00004768996,0.00006804228,0.000002550832],"category_scores_gemma":[0.000668501,0.0000540476,0.00002137765,0.0007006876,0.001154912,0.000135539,0.00004718215,0.0001871968,1.821618e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002050031,"about_ca_system_score_gemma":0.0003345703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002125474,"about_ca_topic_score_gemma":0.000230849,"domain_scores_codex":[0.9985949,0.0001496315,0.0003877126,0.0003644546,0.0003451116,0.0001581558],"domain_scores_gemma":[0.9983094,0.001289815,0.00005357767,0.00009632236,0.0001058486,0.0001450106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001112702,0.0001936626,0.988346,0.0001038892,0.00001363886,0.000005673865,0.001311869,0.00006042409,0.005839682,0.00003487131,7.074246e-7,0.002976917],"study_design_scores_gemma":[0.004248021,0.004046242,0.9602433,0.00006759744,0.0000268109,0.00001693072,0.0002840712,0.03034275,0.0002612276,0.0004136872,0.00000204511,0.00004733598],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990842,0.0001431105,0.00005319971,0.0002017959,0.00003653679,0.0004599518,0.000007749982,0.000006786233,0.000006660611],"genre_scores_gemma":[0.999083,0.00002882175,0.0008427901,0.00002064039,0.00001426443,0.000001568739,0.00000371699,0.000003880487,0.000001293404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03028232,"threshold_uncertainty_score":0.4255323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09487828888287193,"score_gpt":0.4303647959061324,"score_spread":0.3354865070232605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}