{"id":"W4361201958","doi":"10.1111/cts.13515","title":"Relative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling","year":2023,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"Genentech; F. Hoffmann-La Roche","keywords":"Alectinib; Capsule; Cmax; Medicine; Bioavailability; Crossover study; Venipuncture; Pharmacology; Anesthesia; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002038974,0.0007734516,0.001173111,0.0002595653,0.000427401,0.0004057228,0.0002930212,0.0007706754,0.001206765],"category_scores_gemma":[0.002173814,0.0005254561,0.0006329634,0.0002096283,0.0006848981,0.0003323171,0.0002851618,0.0007026744,0.0002618621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003109471,"about_ca_system_score_gemma":0.0004658354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009422312,"about_ca_topic_score_gemma":0.0008159901,"domain_scores_codex":[0.998871,0.0005308756,0.00004533466,0.0002701348,0.0002009881,0.00008155097],"domain_scores_gemma":[0.998899,0.0003205873,0.0002623906,0.0001520625,0.0001517186,0.0002142103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6668724,0.02441171,0.02536154,0.0003757151,0.0009847846,0.0002155519,0.0005260834,0.0007924731,0.2520535,0.0001474408,0.0005605705,0.02769826],"study_design_scores_gemma":[0.02214388,0.8049165,0.1308353,0.00001613218,0.001009356,0.0004304146,0.0002034741,0.002971821,0.03620531,0.0000987953,0.001108136,0.00006081415],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987947,0.0001797693,0.0005169488,0.00001165859,0.00002495198,0.0002375162,0.00008000802,0.00001083738,0.0001434929],"genre_scores_gemma":[0.997754,0.000119151,0.001195942,0.00007180105,0.00003746462,0.0002569752,0.0001739299,0.000006702842,0.0003840244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002038974,"threshold_uncertainty_score":0.01078326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09487828888287193,"score_gpt":0.4303647959061324,"score_spread":0.3354865070232605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}