{"id":"W4361204681","doi":"10.3390/cancers15072015","title":"Filling the Gap after CDK4/6 Inhibitors: Novel Endocrine and Biologic Treatment Options for Metastatic Hormone Receptor Positive Breast Cancer","year":2023,"lang":"en","type":"review","venue":"Cancers","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Fulvestrant; Exemestane; Metastatic breast cancer; Medicine; Everolimus; Oncology; Internal medicine; Palbociclib; Breast cancer; Cancer; Estrogen receptor; Clinical trial; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005417572,0.0004813597,0.0006337943,0.0009086204,0.000249519,0.0009687089,0.0003892978,0.0007458332,0.002743917],"category_scores_gemma":[0.0005539596,0.0001324426,0.0004309967,0.0006398972,0.0003947709,0.001477007,0.0006315389,0.002468496,0.001556322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005475552,"about_ca_system_score_gemma":0.0005906741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004046535,"about_ca_topic_score_gemma":0.001482018,"domain_scores_codex":[0.9997931,0.00005287157,0.00002534873,0.00003438854,0.00006602803,0.00002818349],"domain_scores_gemma":[0.9998091,0.00008588041,0.00002936908,0.00000546638,0.0000471272,0.0000231538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000153999,0.00009210961,0.0002080179,0.005494777,0.00006686594,0.0003106912,0.0001015494,0.0004771842,0.003651814,0.008479914,0.04233728,0.9386258],"study_design_scores_gemma":[0.00002784951,0.0002115544,0.0005541778,0.001601852,0.00006069385,0.001459459,0.0000635852,0.0001962215,0.0009742089,0.004000301,0.9908336,0.00001663817],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005401572,0.9934681,0.0006024013,0.00213244,0.0007934467,0.00001065083,0.00002580355,0.00002542413,0.002401696],"genre_scores_gemma":[0.003127414,0.9909832,0.0008245471,0.001724247,0.00116284,0.00001441406,0.000061441,0.000008279187,0.002093507],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002743917,"threshold_uncertainty_score":0.009179354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09731471734959683,"score_gpt":0.3832936032639684,"score_spread":0.2859788859143715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}