{"id":"W4361205594","doi":"10.2217/epi-2023-0045","title":"Epigenetics-Based Diagnostic and Therapeutic Strategies: Shifting the Paradigm in Prostate Cancer","year":2023,"lang":"en","type":"review","venue":"Epigenomics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Epigenetics; Prostate cancer; Biology; microRNA; Bioinformatics; Cancer; Epigenesis; Non-coding RNA; DNA methylation; Computational biology; Cancer research; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006086748,0.0004363692,0.000657002,0.0001131331,0.0001422924,0.0001371566,0.0003416594,0.0003131979,0.000006528129],"category_scores_gemma":[0.0001405515,0.0003299685,0.0001851252,0.0002619977,0.0001381053,0.000002378133,0.0001318421,0.0003120527,0.00001423026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006562719,"about_ca_system_score_gemma":0.0007722367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001409834,"about_ca_topic_score_gemma":0.000879905,"domain_scores_codex":[0.997896,0.0002730512,0.0006393497,0.0006132232,0.000129621,0.0004487945],"domain_scores_gemma":[0.9985687,0.0004607274,0.0003286038,0.0005298248,0.00003150771,0.00008060272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001857315,0.00005048726,0.0008199071,0.004201644,0.0002442507,0.00001781835,0.0003033361,0.004138819,0.000149815,0.000284043,0.00002176394,0.9897496],"study_design_scores_gemma":[0.0002965598,0.0001341055,0.0006648855,0.001605317,0.0003047639,0.000001754866,0.00008690516,0.0001867059,0.0001654338,0.001296995,0.9946161,0.0006404749],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007323447,0.9908037,0.0001729439,0.00008486035,0.0002502532,0.001173232,0.0001062959,0.00001667979,0.00006864664],"genre_scores_gemma":[0.004782708,0.993865,0.00006946659,0.00006304322,0.0002961066,0.0004346551,0.000231804,0.0001332755,0.0001239544],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9945943,"threshold_uncertainty_score":0.9999152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04953847226581871,"score_gpt":0.3508576548779896,"score_spread":0.3013191826121709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}