{"id":"W4361214884","doi":"10.1158/2159-8290.cd-22-1427","title":"Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kensington Health","funders":"Medical Research Council; Genentech; Ono Pharmaceutical; National Institute for Health and Care Research; Cancer Research UK; Ipsen; Royal Marsden Cancer Charity; Gordon and Rose McAlpine Foundation for Neuroscience Research; Francis Crick Institute; Wellcome Trust; National Cancer Institute; Melanoma Research Alliance; Invitae; Bristol-Myers Squibb; AstraZeneca; Pfizer; Rosetrees Trust; U.S. Department of Defense","keywords":"Biology; Melanoma; Metastasis; Cancer research; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000670993,0.000115988,0.0002487919,0.0001079486,0.0001177423,0.000008588419,0.00007988058,0.00003046825,0.0005534693],"category_scores_gemma":[0.00002434051,0.0001029834,0.0001380211,0.0003858653,0.00006890595,0.0001808187,0.0002516724,0.00008107936,0.00006952424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001241594,"about_ca_system_score_gemma":0.00008260254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006370253,"about_ca_topic_score_gemma":0.00009955437,"domain_scores_codex":[0.9990833,0.00002538815,0.0001872208,0.0002228902,0.0002829835,0.000198149],"domain_scores_gemma":[0.9995438,0.00003424272,0.00008679601,0.0002370032,0.00004455936,0.00005363449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.005663707,0.002169502,0.3266094,0.008697103,0.007381512,0.006367177,0.01914013,0.02122001,0.08655212,0.03446061,0.4452894,0.03644924],"study_design_scores_gemma":[0.009506813,0.002135022,0.6494676,0.001064171,0.002603431,0.0001030788,0.01936579,0.008089315,0.02782395,0.006394271,0.2718889,0.001557627],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992359,0.0006968768,0.0003380677,0.0005452159,0.0006564682,0.0003202693,0.0002166246,0.0001372853,0.00473014],"genre_scores_gemma":[0.9747397,0.001060697,0.00009405279,0.0002558113,0.00008407368,0.00003256515,0.00005074441,0.00001542302,0.02366688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3228582,"threshold_uncertainty_score":0.6060101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04994855857310882,"score_gpt":0.2860617441034797,"score_spread":0.2361131855303709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}