{"id":"W4361214884","doi":"10.1158/2159-8290.cd-22-1427","title":"Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kensington Health","funders":"Medical Research Council; Genentech; Ono Pharmaceutical; National Institute for Health and Care Research; Cancer Research UK; Ipsen; Royal Marsden Cancer Charity; Gordon and Rose McAlpine Foundation for Neuroscience Research; Francis Crick Institute; Wellcome Trust; National Cancer Institute; Melanoma Research Alliance; Invitae; Bristol-Myers Squibb; AstraZeneca; Pfizer; Rosetrees Trust; U.S. Department of Defense","keywords":"Biology; Melanoma; Metastasis; Cancer research; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009206258,0.0002746188,0.0004460768,0.0007099315,0.000536015,0.001548016,0.0003340002,0.0006312443,0.0009116217],"category_scores_gemma":[0.001496004,0.0002503051,0.0002883174,0.0006937959,0.0006496802,0.001235536,0.001265641,0.001990648,0.0004425731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005173984,"about_ca_system_score_gemma":0.0003936433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001341592,"about_ca_topic_score_gemma":0.003886674,"domain_scores_codex":[0.9994794,0.0001117851,0.00003167371,0.0001922784,0.0001184457,0.00006646699],"domain_scores_gemma":[0.9993979,0.000178314,0.0001314173,0.0000736474,0.0001239717,0.00009469537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001093429,0.0001104369,0.335538,0.0009015491,0.0007510089,0.005233095,0.002830572,0.003676339,0.2344978,0.01372472,0.02665737,0.3749857],"study_design_scores_gemma":[0.00005029644,0.0004155832,0.8026686,0.0006322011,0.0002753231,0.01247381,0.002272679,0.005742092,0.01567494,0.03225777,0.1273865,0.0001501924],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8970641,0.03621569,0.02765259,0.02434426,0.0003812847,0.00007761524,0.005868097,0.0003517933,0.008044612],"genre_scores_gemma":[0.9394433,0.03136777,0.01096181,0.007918959,0.0006593084,0.00009360153,0.004759523,0.0001928392,0.004602901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001548016,"threshold_uncertainty_score":0.004868805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04994855857310882,"score_gpt":0.2860617441034797,"score_spread":0.2361131855303709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}