{"id":"W4361215760","doi":"10.1136/gutjnl-2022-327927","title":"FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer","year":2023,"lang":"en","type":"article","venue":"Gut","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Cancer Research UK; Wellcome Trust","keywords":"Immunosurveillance; Cancer research; Biology; KRAS; Pancreatic cancer; Antigen presentation; CD8; Immunotherapy; Cancer immunotherapy; Tumor microenvironment; Antigen processing; Focal adhesion; Immune system; T cell; Immunology; Cancer; Signal transduction; Cell biology; Colorectal cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001869254,0.0002921879,0.000190207,0.0001765629,0.0001534648,0.0004205778,0.0001188664,0.0001900257,0.001712439],"category_scores_gemma":[0.0001289515,0.00009757304,0.0002440461,0.0001475064,0.0001446671,0.0001659098,0.0001905125,0.000402843,0.0003738485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002052338,"about_ca_system_score_gemma":0.0001512909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001223602,"about_ca_topic_score_gemma":0.0002446659,"domain_scores_codex":[0.9998734,0.00001875584,0.00001047573,0.00002552193,0.00003854821,0.00003327958],"domain_scores_gemma":[0.9999169,0.00001138945,0.00003562886,0.000009521451,0.000007122293,0.00001932288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003729667,0.00004580094,0.001700084,0.000216143,0.00002912729,0.00009664357,0.00001689022,0.0002864795,0.9910465,0.0001543737,0.0002272629,0.00580761],"study_design_scores_gemma":[0.00008422927,0.001023555,0.06814811,0.00005447662,0.0001026816,0.001690675,0.0001018582,0.003266291,0.9093871,0.000282719,0.01584292,0.00001548536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906046,0.005551681,0.001478817,0.0002340943,0.00004504983,0.00002227614,0.0005151929,0.00008173238,0.001466594],"genre_scores_gemma":[0.9965431,0.001412129,0.0005092659,0.0000573295,0.00001117374,0.00001833195,0.0004519602,0.00001000759,0.0009867775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001712439,"threshold_uncertainty_score":0.005728662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0403149737686089,"score_gpt":0.3779931406547737,"score_spread":0.3376781668861649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}