{"id":"W4361225952","doi":"10.3390/cells12071032","title":"Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF): An Emerging Therapeutic Target for Neurodegenerative Disorders","year":2023,"lang":"en","type":"review","venue":"Cells","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Cameco (Canada)","funders":"","keywords":"Neurotrophic factors; Astrocyte; Neuroscience; Neurotrophin; Endoplasmic reticulum; Unfolded protein response; Neuroprotection; Glial cell line-derived neurotrophic factor; Biology; Nervous system; Cell biology; Central nervous system; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002462458,0.0006993605,0.0009580416,0.001551267,0.0002419067,0.0008041323,0.0005872499,0.0007713381,0.003767171],"category_scores_gemma":[0.0002326374,0.0001523213,0.0002798604,0.001628472,0.000242766,0.000867115,0.0005720908,0.001395463,0.002851066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003900673,"about_ca_system_score_gemma":0.0007167992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006330847,"about_ca_topic_score_gemma":0.001453409,"domain_scores_codex":[0.9999268,0.000008512688,0.000009806962,0.00001286828,0.00003146031,0.00001051642],"domain_scores_gemma":[0.9999197,0.00002445533,0.00001209986,0.00000321726,0.00002542627,0.00001513409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006379251,0.00005663892,0.00009472146,0.008758783,0.00005596732,0.000258123,0.00004212586,0.0002424421,0.003662165,0.003326741,0.03041201,0.9530265],"study_design_scores_gemma":[0.0000141246,0.00006902072,0.0003624255,0.001210862,0.00006240328,0.001212662,0.00003587503,0.00005916506,0.0005523568,0.00118131,0.9952303,0.000009509651],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002133641,0.9974172,0.0001888679,0.0002442331,0.0002381683,0.000005916027,0.0000327112,0.00001585884,0.001643649],"genre_scores_gemma":[0.0007904914,0.9976833,0.0002304671,0.0001512119,0.0001118448,0.000007541468,0.00005318105,0.000002423421,0.0009696042],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003767171,"threshold_uncertainty_score":0.01260239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0577515519867652,"score_gpt":0.3498444440097442,"score_spread":0.2920928920229791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}