{"id":"W4361239217","doi":"10.1158/0008-5472.c.6499523.v1","title":"Data from <i>PIK3CA</i> and <i>PIK3CB</i> Inhibition Produce Synthetic Lethality when Combined with Estrogen Deprivation in Estrogen Receptor–Positive Breast Cancer","year":2023,"lang":"en","type":"preprint","venue":"","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute; National Institutes of Health; Breast Cancer Research Foundation","keywords":"Cancer research; P110α; Estrogen receptor; Breast cancer; Synthetic lethality; Estrogen; PI3K/AKT/mTOR pathway; Protein subunit; Chemistry; RNA interference; Apoptosis; Cancer; Molecular biology; Biology; Internal medicine; Mutant; Endocrinology; Gene; Medicine; RNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005604524,0.001087257,0.001123221,0.0007866267,0.0006011812,0.0007000397,0.0005727791,0.0008545235,0.02048982],"category_scores_gemma":[0.0005288969,0.0003487011,0.001031421,0.0007610545,0.0007204178,0.0006295381,0.0003551921,0.002923907,0.005041372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008216872,"about_ca_system_score_gemma":0.0009774822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003349885,"about_ca_topic_score_gemma":0.004262317,"domain_scores_codex":[0.9989095,0.00009724808,0.0001973458,0.0002214335,0.0003491187,0.0002253616],"domain_scores_gemma":[0.9991584,0.0001934395,0.000113872,0.0001679723,0.0001257386,0.0002405773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004699839,0.001924978,0.002161007,0.0006113274,0.0002531641,0.0003973648,0.0001435538,0.0008839798,0.956975,0.001476562,0.01298972,0.01748337],"study_design_scores_gemma":[0.0003079436,0.002251302,0.01369101,0.00002803138,0.0001583057,0.0007277353,0.0001775748,0.001228202,0.9386801,0.000367904,0.04233758,0.0000442673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.7644868,0.004462617,0.02309997,0.003135053,0.001572641,0.000761414,0.1415392,0.00235649,0.058586],"genre_scores_gemma":[0.7623977,0.004367622,0.01692768,0.001765685,0.000124445,0.002037634,0.1287212,0.0007351408,0.08292295],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.02048982,"threshold_uncertainty_score":0.06854522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02585950509952587,"score_gpt":0.2669912804678296,"score_spread":0.2411317753683037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}