{"id":"W4361245262","doi":"10.1093/oncolo/oyad008","title":"Niraparib with Abiraterone Acetate and Prednisone for Metastatic Castration-Resistant Prostate Cancer: Phase II QUEST Study Results","year":2023,"lang":"en","type":"article","venue":"The Oncologist","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of British Columbia","funders":"Janssen Biotech; Janssen Research and Development; Amgen; Astellas Foundation for Research on Metabolic Disorders; Astellas Pharma; UroGen Pharma; Dendreon Pharmaceuticals; Progenics Pharmaceuticals; Sanofi; Pfizer; Myriad Genetics; AstraZeneca; Eli Lilly and Company","keywords":"Abiraterone acetate; Medicine; Prostate cancer; Prednisone; Androgen receptor; Abiraterone; Androgen deprivation therapy; Internal medicine; Oncology; Cancer research; PARP1; Testosterone (patch); Pharmacology; Cancer; Poly ADP ribose polymerase; Polymerase; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001018112,0.0002197853,0.0004212264,0.00008139641,0.0004735909,0.000053567,0.0001079999,0.0000359933,0.00001835641],"category_scores_gemma":[0.00008016164,0.0001305783,0.00003679558,0.0003966885,0.0003979168,0.0000960574,0.00004350705,0.0001576257,0.000009122232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001881719,"about_ca_system_score_gemma":0.0003399276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000508857,"about_ca_topic_score_gemma":0.002312942,"domain_scores_codex":[0.9983671,0.0001364999,0.0004420014,0.0004125996,0.0002848227,0.0003569793],"domain_scores_gemma":[0.9988224,0.0002465746,0.0002554058,0.0003901818,0.0001760949,0.0001093343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3546253,0.01637875,0.006513736,0.001596487,0.005368442,0.001747317,0.09675185,0.004139706,0.3096387,0.001372621,0.1167644,0.08510273],"study_design_scores_gemma":[0.458862,0.2386339,0.06999059,0.001448379,0.004788694,0.0004100086,0.037504,0.005950831,0.0512454,0.002522189,0.1265062,0.002137802],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811773,0.0003584306,0.00006614098,0.01260909,0.0001497835,0.004327928,0.000733274,0.0002120965,0.0003659778],"genre_scores_gemma":[0.9916431,0.0003293873,0.0006021159,0.0003782536,0.0001339937,0.002342287,0.0001360467,0.00003911685,0.004395666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2583933,"threshold_uncertainty_score":0.5324827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08989458193043044,"score_gpt":0.4177456472270286,"score_spread":0.3278510652965981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}