{"id":"W4361245271","doi":"10.1093/eurheartj/ehad187","title":"Hypertension, brain imaging phenotypes, and cognitive impairment: lessons from Mendelian randomization","year":2023,"lang":"en","type":"letter","venue":"European Heart Journal","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Mendelian randomization; Medicine; Observational study; Dementia; Cognition; Mendelian inheritance; Cognitive impairment; Phenotype; Blood pressure; Randomization; Neuroimaging; Cognitive decline; Randomized controlled trial; Bioinformatics; Internal medicine; Neuroscience; Psychiatry; Genetics; Disease; Genetic variants; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009143267,0.0008832153,0.001698852,0.0007837359,0.0007202791,0.001589739,0.001537463,0.009394391,0.01503977],"category_scores_gemma":[0.08107195,0.000484959,0.001238656,0.001056354,0.001905404,0.001782335,0.0009174306,0.01050559,0.002084392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009869175,"about_ca_system_score_gemma":0.000768551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003600743,"about_ca_topic_score_gemma":0.003271603,"domain_scores_codex":[0.9957361,0.002891935,0.0002591618,0.0004926206,0.0005132671,0.0001069506],"domain_scores_gemma":[0.9569249,0.03881893,0.001106022,0.001370571,0.001381524,0.0003979774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.002867992,0.00009909095,0.01341729,0.001035798,0.001148363,0.006518309,0.0003111394,0.002617746,0.001116175,0.05089983,0.7067113,0.213257],"study_design_scores_gemma":[0.0038938,0.0004624767,0.01390521,0.001678548,0.001458622,0.01012147,0.0003400788,0.02267613,0.001538903,0.7244434,0.2190776,0.0004037783],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01112597,0.01941605,0.03934187,0.8830502,0.03704332,0.0001116521,0.002007385,0.0009660869,0.006937478],"genre_scores_gemma":[0.3260863,0.03324591,0.03823994,0.3851302,0.2019645,0.0005446582,0.001047031,0.0005864868,0.01315507],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01503977,"threshold_uncertainty_score":0.05031306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02989444897832157,"score_gpt":0.2843928248204706,"score_spread":0.2544983758421491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}