{"id":"W4361253421","doi":"10.34067/kid.0000000000000110","title":"Complex PKD1 Genetics in Early-Onset Cystic Kidney Disease","year":2023,"lang":"en","type":"letter","venue":"Kidney360","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton; Impact","funders":"American Society of Nephrology","keywords":"PKD1; Genetics; Medicine; Disease; Biology; Polycystic kidney disease; Kidney; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001886674,0.0007748296,0.0005978252,0.0002920449,0.0001179434,0.0001093884,0.0009106568,0.001019111,0.0002773408],"category_scores_gemma":[0.001101695,0.0008254183,0.0004079392,0.0003342521,0.000264394,0.000003568426,0.000471717,0.0008299157,0.0007992142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005992577,"about_ca_system_score_gemma":0.00141826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008055573,"about_ca_topic_score_gemma":0.00001346655,"domain_scores_codex":[0.9960268,0.0002954062,0.0006672877,0.001320919,0.0005860084,0.00110358],"domain_scores_gemma":[0.9968872,0.00005489164,0.0002092718,0.001484762,0.0001264114,0.001237458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008801374,0.00007088551,0.009127745,0.0003525495,0.0001110021,0.0007633228,0.0000254669,0.00002261174,0.002174838,9.139968e-7,0.9871891,0.00007355057],"study_design_scores_gemma":[0.001013018,0.0001617289,0.04005788,0.000190359,0.0001915159,0.00001716663,0.00001439261,0.0000927912,0.0004825742,0.0003744891,0.9563905,0.001013606],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1876021,0.005579317,0.0005081446,0.7601269,0.00572951,0.003884068,0.03109942,0.0005656694,0.004904885],"genre_scores_gemma":[0.1302762,0.0008224989,0.0004779424,0.8072701,0.006382767,0.0003536175,0.03853367,0.0004624314,0.01542076],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.05732586,"threshold_uncertainty_score":0.9999788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01946292585228937,"score_gpt":0.2583165854414526,"score_spread":0.2388536595891633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}