{"id":"W4361267302","doi":"10.1371/journal.pone.0283544","title":"Effects of PTH glandular and external dosing patterns on bone cell activity using a two-state receptor model—Implications for bone disease progression and treatment","year":2023,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Bone health and osteoporosis research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Australian Research Council; Bayerische Forschungsallianz; Deutsche Forschungsgemeinschaft; Deutscher Akademischer Austauschdienst","keywords":"Parathyroid hormone; Endocrinology; Internal medicine; Receptor; Homeostasis; Primary hyperparathyroidism; Osteoporosis; Bone remodeling; Teriparatide; Bone cell; Secretion; Medicine; Chemistry; Biology; Calcium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003818091,0.0005010033,0.0008189885,0.0002835087,0.0002794695,0.000924882,0.0007395158,0.001861337,0.003799441],"category_scores_gemma":[0.00119159,0.0003092056,0.001022516,0.0002802997,0.0006538962,0.0003804209,0.000501493,0.0007303241,0.000273777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006515104,"about_ca_system_score_gemma":0.0007058706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01394837,"about_ca_topic_score_gemma":0.005886204,"domain_scores_codex":[0.9998462,0.0000484362,0.000006285179,0.00002618567,0.00002935483,0.00004354437],"domain_scores_gemma":[0.9994943,0.0003089703,0.00006740708,0.00002308862,0.00006685285,0.00003936543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00005363995,0.00003051335,0.000412931,0.00002659283,0.00001018337,0.00007008174,0.00001941065,0.9950429,0.001778024,0.001671236,0.00009610112,0.0007884009],"study_design_scores_gemma":[0.00001112351,0.0000241527,0.0001305482,0.000002526516,0.00000737811,0.000009194176,0.000008496511,0.9991733,0.0001935341,0.0003255886,0.0001104915,0.000003643058],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6987531,0.00214595,0.2618377,0.002091881,0.0001870147,0.0001643342,0.0009538868,0.0004492637,0.03341693],"genre_scores_gemma":[0.9885414,0.0003488939,0.00546843,0.0001020969,0.00001082477,0.00009117922,0.000113647,0.00001947667,0.005303953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01394837,"threshold_uncertainty_score":0.0277344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08872707448344033,"score_gpt":0.3659636268411328,"score_spread":0.2772365523576925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}