{"id":"W4361268193","doi":"10.3390/children10040647","title":"Holoprosencephaly: Review of Embryology, Clinical Phenotypes, Etiology and Management","year":2023,"lang":"en","type":"review","venue":"Children","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Universidade de São Paulo","keywords":"Holoprosencephaly; Etiology; Sonic hedgehog; Embryology; Biology; Phenotype; Bioinformatics; Pathology; Medicine; Anatomy; Genetics; Pregnancy; Fetus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004306184,0.0009170356,0.001333783,0.003162081,0.0002798004,0.000726237,0.0008643027,0.0006969948,0.003127538],"category_scores_gemma":[0.001154289,0.0002734134,0.0005036963,0.00313424,0.0004222411,0.001092018,0.0005142424,0.001331061,0.001206034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005092344,"about_ca_system_score_gemma":0.00103725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001226084,"about_ca_topic_score_gemma":0.001967344,"domain_scores_codex":[0.9998003,0.00003042728,0.0000575458,0.00003970564,0.00005657421,0.00001544359],"domain_scores_gemma":[0.9995224,0.0002744502,0.00006839134,0.0000112316,0.0000860627,0.00003744911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006041399,0.00005065345,0.0005778082,0.01742476,0.000108971,0.000910497,0.00007945276,0.0003959121,0.0008680251,0.001455078,0.03978724,0.9382812],"study_design_scores_gemma":[0.00002291621,0.0001180004,0.003861766,0.01208151,0.0003846802,0.01698139,0.0001416874,0.0001428152,0.0003409992,0.00214987,0.9637325,0.00004193069],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001887721,0.9985771,0.0001335507,0.0002374457,0.0001754974,0.000003941828,0.00003282403,0.00001114936,0.0006397566],"genre_scores_gemma":[0.0007175171,0.9983524,0.0002643638,0.0001494646,0.000211616,0.000005342028,0.00005914448,0.0000022222,0.0002378763],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003162081,"threshold_uncertainty_score":0.0104627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0787122819899506,"score_gpt":0.4090119464627948,"score_spread":0.3302996644728441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}