{"id":"W4361268193","doi":"10.3390/children10040647","title":"Holoprosencephaly: Review of Embryology, Clinical Phenotypes, Etiology and Management","year":2023,"lang":"en","type":"review","venue":"Children","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Universidade de São Paulo","keywords":"Holoprosencephaly; Etiology; Sonic hedgehog; Embryology; Biology; Phenotype; Bioinformatics; Pathology; Medicine; Anatomy; Genetics; Pregnancy; Fetus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008680215,0.0003429217,0.001670113,0.00007674102,0.0000469378,0.00000445862,0.0003653741,0.0004455899,0.000008861956],"category_scores_gemma":[0.0002826279,0.0002748665,0.0004082095,0.0001693133,0.0003955229,8.903604e-7,0.0006606543,0.0002268484,0.00006596353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007580257,"about_ca_system_score_gemma":0.00008431914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003444047,"about_ca_topic_score_gemma":0.00000266259,"domain_scores_codex":[0.9976653,0.0003423046,0.0009214892,0.0007164936,0.00009459555,0.0002598546],"domain_scores_gemma":[0.9987707,0.00006728571,0.0004338641,0.0006021571,0.00005734024,0.00006861977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000006759546,0.00006415884,0.0003763727,0.1049926,0.002210252,0.00001332224,0.000005212463,6.693559e-8,0.00000356675,0.0001971764,0.02173416,0.8703964],"study_design_scores_gemma":[0.0001926655,0.0001879155,0.0009047087,0.03184294,0.001157554,0.00005120949,0.000002452756,4.070718e-8,0.000004094814,0.00002704464,0.9653151,0.0003142846],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001046943,0.9979405,0.00001665781,0.00003384773,0.0002491354,0.001002828,0.0001146688,0.00002485638,0.0005128554],"genre_scores_gemma":[0.000004943727,0.9976007,0.0002686803,0.0002425777,0.0003384285,0.0001047538,0.0008220187,0.00005556042,0.0005623618],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9435809,"threshold_uncertainty_score":0.9999704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0787122819899506,"score_gpt":0.4090119464627948,"score_spread":0.3302996644728441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}