{"id":"W4361269749","doi":"10.1016/j.cell.2023.03.008","title":"Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting","year":2023,"lang":"en","type":"review","venue":"Cell","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":210,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; Dana-Farber Cancer Institute; National Institute of Mental Health; Brigham and Women's Hospital; National Cancer Institute; National Institutes of Health; Multiple Sclerosis Society of Canada; International Progressive MS Alliance; National Multiple Sclerosis Society; American Cancer Society","keywords":"Multiple sclerosis; Biology; Crosstalk; Disease; Neuroimmunology; Immune system; Neuroscience; Pathogenesis; Immunology; Neuroinflammation; Central nervous system; Bioinformatics; Inflammation; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001593772,0.001455361,0.002776101,0.003895566,0.0003147076,0.002027306,0.001029441,0.002232813,0.0063344],"category_scores_gemma":[0.002075845,0.0004383271,0.0007645928,0.003797629,0.0007541832,0.001739552,0.001352574,0.002212461,0.00207167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009965408,"about_ca_system_score_gemma":0.002597315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001510292,"about_ca_topic_score_gemma":0.004103677,"domain_scores_codex":[0.9995802,0.0001124935,0.00008254494,0.00005741846,0.0001241734,0.00004310607],"domain_scores_gemma":[0.9990061,0.0006073303,0.000137095,0.00002191206,0.0001611059,0.00006654269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002445062,0.00008578546,0.0001216115,0.05461928,0.0002692984,0.0001348284,0.00006430355,0.0003296682,0.0008030382,0.003075993,0.04933932,0.8909125],"study_design_scores_gemma":[0.0001542264,0.0001874292,0.0006676461,0.02502294,0.0007790945,0.0006223918,0.00009223965,0.0001022666,0.0002534529,0.002190098,0.9698972,0.00003109404],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002190971,0.9993346,0.00002960765,0.0001872536,0.0001605739,0.000003393273,0.0000110899,0.000002657534,0.0002489901],"genre_scores_gemma":[0.0002129452,0.9990952,0.00006619453,0.0002501159,0.0001793847,0.000005597404,0.00001364364,5.826258e-7,0.0001763797],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0063344,"threshold_uncertainty_score":0.02119064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2267963401686796,"score_gpt":0.3740827647711066,"score_spread":0.147286424602427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}