{"id":"W4361269749","doi":"10.1016/j.cell.2023.03.008","title":"Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting","year":2023,"lang":"en","type":"review","venue":"Cell","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":210,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; Dana-Farber Cancer Institute; National Institute of Mental Health; Brigham and Women's Hospital; National Cancer Institute; National Institutes of Health; Multiple Sclerosis Society of Canada; International Progressive MS Alliance; National Multiple Sclerosis Society; American Cancer Society","keywords":"Multiple sclerosis; Biology; Crosstalk; Disease; Neuroimmunology; Immune system; Neuroscience; Pathogenesis; Immunology; Neuroinflammation; Central nervous system; Bioinformatics; Inflammation; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004918677,0.0005236337,0.001945283,0.000252679,0.0002747281,0.00009648412,0.000225952,0.0002516796,0.00005886447],"category_scores_gemma":[0.0006242286,0.0003882217,0.0004460734,0.0004876384,0.0002566271,0.00003508113,0.0005037478,0.0008237268,0.0005135317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009156449,"about_ca_system_score_gemma":0.000170693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004572545,"about_ca_topic_score_gemma":0.000004697711,"domain_scores_codex":[0.9973402,0.0001848632,0.000661327,0.000697496,0.0004457581,0.0006703718],"domain_scores_gemma":[0.9979787,0.0009040958,0.0002277063,0.0005652703,0.0001056222,0.0002185826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002182275,0.0001291944,0.0001081705,0.06811852,0.0003914511,0.00006072056,0.0002123394,4.126688e-7,0.0009039756,0.000001282593,0.002841113,0.927211],"study_design_scores_gemma":[0.0008996931,0.0001102924,0.001218226,0.01402995,0.0005976785,0.00001009318,0.00008782253,0.00006773732,0.00004037811,0.000002513445,0.9825926,0.0003430027],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001965053,0.996861,0.000003407194,0.00005246157,0.0002326204,0.00167807,0.00005682615,0.0002345274,0.0006845361],"genre_scores_gemma":[0.000486983,0.9950806,0.000118504,0.00005630012,0.0002888785,0.000284185,0.0001041142,0.0001971694,0.003383276],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9797515,"threshold_uncertainty_score":0.9998569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2267963401686796,"score_gpt":0.3740827647711066,"score_spread":0.147286424602427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}