{"id":"W4361271086","doi":"10.3389/fcimb.2023.1149419","title":"Evaluation of Mycobacterium avium subsp. paratuberculosis isocitrate lyase (IcL) and ABC transporter (BacA) knockout mutants as vaccine candidates","year":2023,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Agriculture Funding Consortium","keywords":"Biology; Microbiology; Wild type; Immunogenicity; Paratuberculosis; Mutant; Proinflammatory cytokine; Immune system; Virology; Mycobacterium; Gene; Immunology; Bacteria; Inflammation; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003435146,0.0004999037,0.0005592936,0.0002526226,0.0001044485,0.0003505681,0.0003850781,0.0004313113,0.0007360475],"category_scores_gemma":[0.000213555,0.0001634254,0.0002927246,0.000170431,0.0002032748,0.0002138682,0.0001766547,0.000698988,0.0002073921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002099802,"about_ca_system_score_gemma":0.0002033907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004746925,"about_ca_topic_score_gemma":0.000642926,"domain_scores_codex":[0.9997379,0.00004751674,0.00002952993,0.00004794713,0.00008150272,0.00005550323],"domain_scores_gemma":[0.9997991,0.00004115189,0.00005831369,0.00001529161,0.0000315869,0.00005460487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002267193,0.0001329261,0.0001212933,0.00004078004,0.000005686615,0.00003798599,0.00001135964,0.00008888062,0.9987031,0.00003179156,0.00001654708,0.0005829118],"study_design_scores_gemma":[0.0001108042,0.007598825,0.0026006,0.00001528896,0.00007362505,0.0003430264,0.00006627301,0.001354307,0.9856474,0.0000324838,0.002146902,0.00001031488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974396,0.0006855379,0.001194497,0.00005767751,0.00002739771,0.00006482482,0.0002338275,0.00002375474,0.0002728491],"genre_scores_gemma":[0.9929904,0.001019148,0.003375136,0.00006091663,0.00001274974,0.0001189541,0.0006697511,0.00002303619,0.001729898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007360475,"threshold_uncertainty_score":0.002462387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01672532953984092,"score_gpt":0.2801071919001217,"score_spread":0.2633818623602808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}