{"id":"W4361271318","doi":"10.7554/elife.83810","title":"RNA Polymerase II transcription independent of TBP in murine embryonic stem cells","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Sigrid Juséliuksen Säätiö; Michael Smith Health Research BC; BC Children's Hospital; Children's Hospital Foundation","keywords":"Transcription factor II A; Transcription factor II D; RNA polymerase II; Transcription factor II B; General transcription factor; RNA polymerase III; TATA-Box Binding Protein; RNA polymerase II holoenzyme; Transcription (linguistics); TATA-binding protein; Molecular biology; Cell biology; Biology; Transcription factor II E; Promoter; RNA polymerase I; Chemistry; RNA polymerase; RNA; Genetics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002316259,0.0004403506,0.0002929047,0.0005461739,0.0002424868,0.0004911181,0.0004857917,0.0003405444,0.002197472],"category_scores_gemma":[0.0001323357,0.0004598367,0.0003774047,0.0003112318,0.0003735281,0.0002146402,0.0003425623,0.001055452,0.001917197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005780788,"about_ca_system_score_gemma":0.0004179757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00150626,"about_ca_topic_score_gemma":0.003045885,"domain_scores_codex":[0.9996771,0.00003562561,0.00004776089,0.00008598395,0.000112446,0.00004101828],"domain_scores_gemma":[0.9997633,0.0000260213,0.0000573143,0.00006098876,0.00002530318,0.00006708412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008935155,0.00001290278,0.0001238657,0.0000281137,0.000003710451,0.00004009313,0.00001422016,0.00006016649,0.9980397,0.0002154236,0.00008150617,0.001291036],"study_design_scores_gemma":[0.00002710086,0.0001276662,0.001905783,0.00001235315,0.000009906084,0.0001093242,0.00001048155,0.0005452378,0.9885744,0.00006995515,0.008603974,0.000003938783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9301121,0.008865208,0.03274259,0.0005786953,0.0003324133,0.0003580017,0.01222057,0.001148806,0.01364164],"genre_scores_gemma":[0.9293836,0.0032841,0.02341044,0.0002843251,0.00005457704,0.0003884161,0.01025779,0.0003237248,0.032613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002197472,"threshold_uncertainty_score":0.007351279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008144301958796486,"score_gpt":0.2170169988970124,"score_spread":0.2088726969382159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}