{"id":"W4361271318","doi":"10.7554/elife.83810","title":"RNA Polymerase II transcription independent of TBP in murine embryonic stem cells","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Sigrid Juséliuksen Säätiö; Michael Smith Health Research BC; BC Children's Hospital; Children's Hospital Foundation","keywords":"Transcription factor II A; Transcription factor II D; RNA polymerase II; Transcription factor II B; General transcription factor; RNA polymerase III; TATA-Box Binding Protein; RNA polymerase II holoenzyme; Transcription (linguistics); TATA-binding protein; Molecular biology; Cell biology; Biology; Transcription factor II E; Promoter; RNA polymerase I; Chemistry; RNA polymerase; RNA; Genetics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001490943,0.00009219188,0.0001152051,0.00006445527,0.00002967029,0.000005459637,0.0001265485,0.00009799466,0.0000144857],"category_scores_gemma":[0.000003187432,0.00009610971,0.00006477029,0.0001188351,0.00001986992,0.000001664027,0.00007458174,0.00006148223,0.00001454428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001331876,"about_ca_system_score_gemma":0.00004746811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003724778,"about_ca_topic_score_gemma":0.0001134259,"domain_scores_codex":[0.9992992,0.00002342432,0.0002020407,0.0001868983,0.0001183253,0.0001700771],"domain_scores_gemma":[0.9996561,0.000003204311,0.00005899068,0.0002131339,0.00002490837,0.00004363752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002272043,0.00005165682,0.0005974535,0.0000254768,0.00001495584,0.000004095656,0.0001132975,0.0006635828,0.997117,0.00003864105,0.0004043591,0.0009467526],"study_design_scores_gemma":[0.0006575579,0.0001571969,0.005375842,0.00001381683,0.000006784021,0.000002234603,0.0001571922,0.001246708,0.9903008,0.00001214215,0.001950578,0.0001191762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998921,0.0003332468,0.00007139198,0.00008616395,0.0001744627,0.0001021879,0.00003480089,0.00001047846,0.0002662523],"genre_scores_gemma":[0.9976804,0.0004649044,0.00005580478,0.00006915069,0.000058848,0.000008800621,0.00007622962,0.00001647348,0.001569395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006816237,"threshold_uncertainty_score":0.391924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008144301958796486,"score_gpt":0.2170169988970124,"score_spread":0.2088726969382159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}