{"id":"W4361273166","doi":"10.3390/curroncol30040293","title":"Pancreatic Ductal Adenocarcinoma and Immune Checkpoint Inhibitors: The Gray Curtain of Immunotherapy and Spikes of Lights","year":2023,"lang":"en","type":"review","venue":"Current Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Servier; Incyte; Sanofi; Exelixis; FibroGen; Gilead Sciences; Eisai; Ipsen; BeiGene; Eli Lilly and Company; AstraZeneca; Agios Pharmaceuticals","keywords":"Medicine; Immunotherapy; Pancreatic ductal adenocarcinoma; Tumor microenvironment; Disease; Oncology; Immune checkpoint; Immune system; Internal medicine; Cancer research; Pancreatic cancer; Immunology; Cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000543116,0.0004434397,0.0009271517,0.001690823,0.0002309601,0.000995671,0.0004886318,0.0008290309,0.004083919],"category_scores_gemma":[0.0008580875,0.0001675781,0.0006073423,0.001677606,0.0003570436,0.001264517,0.0005858645,0.00170984,0.001581331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004972995,"about_ca_system_score_gemma":0.001181206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008666431,"about_ca_topic_score_gemma":0.002087543,"domain_scores_codex":[0.9998086,0.00004537635,0.00002725968,0.00002815408,0.00007018401,0.00002043056],"domain_scores_gemma":[0.9996701,0.0001606201,0.00004350507,0.000009599169,0.00008908827,0.00002706046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001048069,0.00004614362,0.0002110641,0.01682937,0.000116846,0.0001878516,0.00007654636,0.0002101756,0.00134487,0.00430465,0.04348543,0.9330822],"study_design_scores_gemma":[0.0000170846,0.00009834192,0.0006565626,0.005361939,0.0001248029,0.0009966249,0.00007260759,0.00006322567,0.0003168576,0.002020752,0.9902576,0.00001354381],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001225874,0.9979984,0.00007553493,0.0007386755,0.0002606613,0.000003243029,0.00001878351,0.000007778405,0.0007743146],"genre_scores_gemma":[0.0006572483,0.9980415,0.0001151833,0.0004464703,0.0002362252,0.000003567411,0.00002880099,0.00000182481,0.0004690781],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004083919,"threshold_uncertainty_score":0.0136621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1635430845134313,"score_gpt":0.4584466402961698,"score_spread":0.2949035557827385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}