{"id":"W4361277981","doi":"10.1002/adtp.202300005","title":"Non‐Viral Nucleic Acid Delivery System for RNA Therapeutics","year":2023,"lang":"en","type":"article","venue":"Advanced Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada)","funders":"","keywords":"Nucleic acid; Drug delivery; Chemistry; RNA; Conjugate; Nanoparticle; Drug; Biochemistry; Nanotechnology; Biology; Gene; Materials science; Pharmacology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001437122,0.000269857,0.0002219211,0.00007754822,0.0001736923,0.00004028636,0.0003782077,0.0002143065,0.000004239144],"category_scores_gemma":[0.00000552848,0.000256131,0.0002058632,0.0001733621,0.00007235388,0.00001222728,0.00009654628,0.0001085166,0.0001214739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003330146,"about_ca_system_score_gemma":0.00006561964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002580905,"about_ca_topic_score_gemma":0.000007384008,"domain_scores_codex":[0.9985957,0.00002900798,0.0002869751,0.0004395163,0.0001523836,0.0004964675],"domain_scores_gemma":[0.9990845,0.00002468095,0.0001099724,0.0005299263,0.00018366,0.00006721914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000266351,0.00002918679,0.0001681623,0.00004289705,0.0002067937,0.000003673324,0.00009148835,0.0003303334,0.9373642,0.00013456,0.0001459571,0.06121645],"study_design_scores_gemma":[0.001120141,0.0007538573,0.0004973965,0.00003951209,0.00008956686,0.000009014078,0.0006300043,0.002340718,0.8972558,0.0002633276,0.09658603,0.0004146215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914678,0.001308703,0.005000532,0.0001628739,0.000782705,0.0004490251,0.00007979785,0.0001338132,0.0006147465],"genre_scores_gemma":[0.9944284,0.001518821,0.0009312447,0.001249371,0.0003150106,0.0001027007,0.0002184827,0.00007922024,0.001156747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09644007,"threshold_uncertainty_score":0.9999891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02150008047819845,"score_gpt":0.2791273731334022,"score_spread":0.2576272926552038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}