{"id":"W4361282797","doi":"10.1182/blood.2022016322","title":"STAT5 activation promotes progression and chemotherapy-resistance in early T-cell precursor acute lymphoblastic leukemia","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"","keywords":"STAT5; Cancer research; Leukemia; Biology; Immunology; Medicine; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001156076,0.0002287567,0.0002093978,0.000320524,0.0001402127,0.0003714922,0.000108435,0.0002343956,0.001360643],"category_scores_gemma":[0.00009603829,0.0001480996,0.0002178647,0.0002038151,0.0001746567,0.0002036222,0.0001824811,0.0006394133,0.0004393097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000326047,"about_ca_system_score_gemma":0.0002193333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005658886,"about_ca_topic_score_gemma":0.0009106468,"domain_scores_codex":[0.9998592,0.00002224308,0.00001359661,0.00002217585,0.0000353448,0.00004736265],"domain_scores_gemma":[0.9999043,0.000009802541,0.00002983282,0.000008395015,0.000005583163,0.00004213904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000883302,0.0001432945,0.00264445,0.0000727521,0.000009403834,0.0001863026,0.00004157135,0.000162054,0.9929414,0.0002659454,0.0002016322,0.002447947],"study_design_scores_gemma":[0.0002472451,0.002369407,0.1156468,0.00003367181,0.0001037078,0.001680955,0.0002097729,0.003800498,0.8661558,0.0002535841,0.009480102,0.0000183854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969102,0.001482223,0.0004104643,0.00006496123,0.00001489249,0.00001597039,0.0002687433,0.00006963305,0.0007631218],"genre_scores_gemma":[0.9979284,0.0005275801,0.0002228141,0.0000441797,0.000005511879,0.00001968481,0.0003780799,0.000007980065,0.000865864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001360643,"threshold_uncertainty_score":0.004551828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01077126254314505,"score_gpt":0.2760829791442148,"score_spread":0.2653117166010697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}