{"id":"W4361284061","doi":"10.3390/biology12040511","title":"Leucine Repeat Rich Kinase 1 Controls Osteoclast Activity by Managing Lysosomal Trafficking and Secretion","year":2023,"lang":"en","type":"article","venue":"Biology","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; U.S. Department of Veterans Affairs","keywords":"Osteoclast; Cathepsin K; Cathepsin; Vacuole; Biology; Cytoplasm; Extracellular; Lysosome; Acridine orange; Intracellular; Cathepsin D; Cell biology; Bone resorption; Staining; Resorption; Secretion; Molecular biology; Biochemistry; In vitro; Endocrinology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002690902,0.0005688277,0.0004747153,0.0003949041,0.000299929,0.0007493375,0.0004402372,0.000539851,0.0009391319],"category_scores_gemma":[0.0002568945,0.0002432245,0.0003216042,0.0001874484,0.0005339144,0.0003004685,0.0004120965,0.0007886984,0.0005208118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005291765,"about_ca_system_score_gemma":0.0003401056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007595309,"about_ca_topic_score_gemma":0.001731167,"domain_scores_codex":[0.9996722,0.0000508188,0.00004012139,0.00007819787,0.0000806419,0.00007796628],"domain_scores_gemma":[0.9996967,0.00002700194,0.0001500721,0.0000215595,0.00003022286,0.0000744368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001785447,0.00002436708,0.0004164447,0.00004695441,0.000005243553,0.0001239779,0.00002055043,0.00009981827,0.9973418,0.0001915286,0.00007384746,0.001476823],"study_design_scores_gemma":[0.0001294144,0.0005008376,0.0132918,0.00001861034,0.00004701738,0.001314385,0.0001150283,0.003483586,0.9735385,0.0004280786,0.007090025,0.00004272017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881884,0.005060924,0.003920062,0.0002574385,0.00005317329,0.00004058441,0.0005011628,0.0002487679,0.001729549],"genre_scores_gemma":[0.9924296,0.001519235,0.002889818,0.00006927534,0.00001702876,0.000047526,0.0002879725,0.0000593892,0.002680081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009391319,"threshold_uncertainty_score":0.003839433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009109440469795591,"score_gpt":0.2478112548549602,"score_spread":0.2387018143851646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}