{"id":"W4361284061","doi":"10.3390/biology12040511","title":"Leucine Repeat Rich Kinase 1 Controls Osteoclast Activity by Managing Lysosomal Trafficking and Secretion","year":2023,"lang":"en","type":"article","venue":"Biology","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; U.S. Department of Veterans Affairs","keywords":"Osteoclast; Cathepsin K; Cathepsin; Vacuole; Biology; Cytoplasm; Extracellular; Lysosome; Acridine orange; Intracellular; Cathepsin D; Cell biology; Bone resorption; Staining; Resorption; Secretion; Molecular biology; Biochemistry; In vitro; Endocrinology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000140132,0.0001372836,0.0001750076,0.00005076419,0.00009456004,0.00001707015,0.0000744377,0.0001445184,0.00001073057],"category_scores_gemma":[0.0000883707,0.0001249295,0.00004874667,0.00009709795,0.00009663364,0.000004654044,0.0001073689,0.00005557118,0.00001164408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004906555,"about_ca_system_score_gemma":0.00002044403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002935536,"about_ca_topic_score_gemma":0.00001559221,"domain_scores_codex":[0.9990733,0.0001099271,0.0001165868,0.0003903634,0.00004309013,0.0002667532],"domain_scores_gemma":[0.9996078,0.00002562799,0.00005616939,0.0002011876,0.00002518468,0.00008403868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001729684,0.00002638565,0.009721046,0.00001503335,0.00002858016,0.000006156748,0.00001497026,0.000009417513,0.9724067,0.0001191227,0.002230131,0.01524948],"study_design_scores_gemma":[0.008785609,0.001417811,0.2304194,0.00005282834,0.0002960705,0.00009946893,0.0004572373,0.003120864,0.530085,0.0008058014,0.2228905,0.001569419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957369,0.002473826,0.000597275,0.0004013318,0.0001647003,0.0001297961,0.00006875605,0.00005530817,0.0003721058],"genre_scores_gemma":[0.9980992,0.0005605998,0.00003119861,0.0002019134,0.0002305351,0.00002282357,0.0004994291,0.00001474355,0.0003395225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4423217,"threshold_uncertainty_score":0.5094476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009109440469795591,"score_gpt":0.2478112548549602,"score_spread":0.2387018143851646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}