{"id":"W4361286052","doi":"10.3390/v15040871","title":"SARS-CoV-2 ORF8: A Rapidly Evolving Immune and Viral Modulator in COVID-19","year":2023,"lang":"en","type":"review","venue":"Viruses","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Pandemic; Viral pathogenesis; Virology; Immune system; Viral replication; Evasion (ethics); Pathogenesis; Coronavirus disease 2019 (COVID-19); Viral evolution; Immunity; Disease; Biology; Host (biology); Virus; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Immunology; Medicine; Infectious disease (medical specialty); Genome; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00112159,0.0007178803,0.00277709,0.001484456,0.0001435786,0.0001765913,0.0004766133,0.0006307962,0.00002450681],"category_scores_gemma":[0.002562952,0.0005860148,0.0005100383,0.001483198,0.00026803,0.0002565562,0.000498183,0.001126477,0.0007289984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006923191,"about_ca_system_score_gemma":0.002439872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002316477,"about_ca_topic_score_gemma":0.0002570218,"domain_scores_codex":[0.995896,0.0003442956,0.001144013,0.00101923,0.0007335413,0.0008628797],"domain_scores_gemma":[0.9976244,0.0009207026,0.0002796291,0.0009610459,0.00008673238,0.0001274701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005029553,0.0005587775,0.002510702,0.1584433,0.001381085,0.00408259,0.0007449941,2.492723e-7,0.01685728,0.0003533453,0.006535517,0.8080292],"study_design_scores_gemma":[0.001460444,0.0001832214,0.00005619312,0.01485581,0.0003739974,0.0001416053,0.00004519503,0.00004388025,0.001142213,0.0001164248,0.9810466,0.0005343998],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007490696,0.9896057,0.00001520439,0.00006832951,0.0002624169,0.001824875,0.00007948268,0.0003164454,0.0003368465],"genre_scores_gemma":[0.0001602287,0.9696854,0.0000829062,0.02890933,0.000427425,0.0004242726,0.00002127106,0.0002368889,0.0000522554],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9745111,"threshold_uncertainty_score":0.9996591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1802867068896376,"score_gpt":0.4494896878807235,"score_spread":0.2692029809910859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}