{"id":"W4361286727","doi":"10.1002/chem.202300618","title":"Redox Reporter ‐ Ligand Competition to Support Signaling in the Cocaine‐Binding Electrochemical Aptamer‐Based Biosensor","year":2023,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; Université de Sherbrooke","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; York University","keywords":"Aptamer; Redox; Chemistry; Ligand (biochemistry); Biosensor; Methylene blue; Conformational change; Biophysics; Electron transfer; Combinatorial chemistry; Photochemistry; Stereochemistry; Biochemistry; Receptor; Inorganic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009287153,0.0004206799,0.0005289397,0.0001786911,0.0002062726,0.0004767283,0.0009834124,0.0007742115,0.001421402],"category_scores_gemma":[0.001065317,0.0002893073,0.0002318718,0.0001845039,0.0003424769,0.0005898786,0.0004534558,0.001209396,0.0005752712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004070169,"about_ca_system_score_gemma":0.0003760316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004272547,"about_ca_topic_score_gemma":0.0008554975,"domain_scores_codex":[0.9991296,0.0002040151,0.00005761182,0.0001933484,0.0002932144,0.0001222216],"domain_scores_gemma":[0.9993117,0.0003875217,0.00009621821,0.00004610141,0.0000966935,0.0000616871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004556038,0.00003210162,0.00007272519,0.00002866251,0.000004443625,0.00002890547,0.00001462097,0.0001188802,0.9984156,0.0003328823,0.0000370879,0.0008685447],"study_design_scores_gemma":[0.000005900846,0.00005092966,0.0001157956,0.000001669465,0.000002657914,0.00005364705,0.000004240544,0.002586312,0.996588,0.00003824801,0.0005483864,0.000004267579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8811309,0.00126363,0.113207,0.0005197115,0.0001440531,0.000163262,0.0001943105,0.0003986448,0.002978498],"genre_scores_gemma":[0.938498,0.0004942344,0.05787277,0.0003183359,0.00003218287,0.0001191356,0.000181608,0.0000586284,0.002425025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001421402,"threshold_uncertainty_score":0.004911602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01638883069385661,"score_gpt":0.2730380278314067,"score_spread":0.2566491971375501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}