{"id":"W4361286751","doi":"10.1038/s41598-023-32257-5","title":"Nanocomposite formulation for a sustained release of free drug and drug-loaded responsive nanoparticles: an approach for a local therapy of glioblastoma multiforme","year":2023,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"H2020 European Research Council; European Commission; Horizon 2020 Framework Programme; Trinity College Dublin; Wellcome Trust","keywords":"Temozolomide; In vivo; Paclitaxel; Medicine; Drug; Glioblastoma; Chemotherapy; U87; Cancer research; In vitro; Glioma; Pharmacology; Oncology; Surgery; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001139728,0.000339932,0.0001677882,0.0001960824,0.0001064096,0.0001861709,0.0001414741,0.0003262311,0.0005328917],"category_scores_gemma":[0.0001088185,0.0001494329,0.0002070507,0.00008826041,0.0001307702,0.0002495626,0.0001501011,0.0003938158,0.0001550106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002694835,"about_ca_system_score_gemma":0.0001889336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005558737,"about_ca_topic_score_gemma":0.001145932,"domain_scores_codex":[0.9999359,0.000006704392,0.000004432051,0.00002017014,0.00002252933,0.00001029155],"domain_scores_gemma":[0.9999441,0.000009497812,0.00002166576,0.000002619622,0.00001070839,0.00001139063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003989952,0.00003764329,0.00003458483,0.00007829272,0.000005094107,0.00004984026,0.00001310267,0.0002113128,0.9963858,0.0001275442,0.00006138612,0.002955465],"study_design_scores_gemma":[0.00001692724,0.0003851895,0.0005781409,0.000007761237,0.00002009925,0.0001954358,0.000009648738,0.002378165,0.9933038,0.00003081169,0.003063028,0.0000108665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9399049,0.006227482,0.04816451,0.0003931071,0.000174709,0.000205624,0.000249171,0.000349383,0.004331126],"genre_scores_gemma":[0.9801485,0.001417717,0.01518699,0.0000886976,0.00002581848,0.00009265487,0.00009556907,0.00003305788,0.00291093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005558737,"threshold_uncertainty_score":0.001955271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01763601755225328,"score_gpt":0.2796840163782109,"score_spread":0.2620479988259576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}