{"id":"W4361293596","doi":"10.1091/mbc.e23-01-0024","title":"Regulation of neurofilament length and transport by a dynamic cycle of phospho-dependent polymer severing and annealing","year":2023,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; University of California, San Diego; National Institutes of Health; King's College London; Université Laval","keywords":"Neurofilament; Biology; Phosphorylation; Polymer; Cell biology; Biophysics; Annealing (glass); Materials science; Immunology; Composite material","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002416165,0.0001110205,0.0001825786,0.00004596724,0.00003644519,0.000001433025,0.0001633401,0.0001625096,0.000004869188],"category_scores_gemma":[0.0000162712,0.00008988346,0.00007394129,0.0001000337,0.0003324019,0.000001509435,0.0001624675,0.00007219025,3.343393e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003431831,"about_ca_system_score_gemma":0.000023175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004832022,"about_ca_topic_score_gemma":0.000004324055,"domain_scores_codex":[0.9991385,0.0001110908,0.0002287485,0.0002640268,0.00008071054,0.0001769208],"domain_scores_gemma":[0.9995198,0.00001522775,0.0001255842,0.0002689536,0.0000358573,0.00003461596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006663169,0.00002575434,0.007628054,0.00005886392,0.00004557189,0.000001515262,0.00004831354,0.00004568183,0.9914559,0.00002842773,0.00001441825,0.0005809199],"study_design_scores_gemma":[0.0004308334,0.0001968985,0.007356609,0.00001326453,0.00002325488,0.00001076692,0.00005588454,0.0003011521,0.9913672,0.00008515923,0.00007893993,0.00008003919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952329,0.00393162,0.0003717658,0.0000938328,0.00005009887,0.0001574594,0.00004310752,0.000004624078,0.0001145461],"genre_scores_gemma":[0.9987701,0.0007172399,0.00007302845,0.00002395581,0.000004939427,0.000005316494,0.0000973904,0.00001377485,0.0002943077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003537101,"threshold_uncertainty_score":0.3665341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004109320655561864,"score_gpt":0.2332130171509179,"score_spread":0.2291036964953561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}